Kenneth Kaye is in the Division of Infectious Diseases at Brigham and Women's Hospital and Harvard Medical School. His research group focuses on the association between Kaposi's sarcoma-associated herpesvirus (KSHV) (also known as human herpesvirus 8 (HHV-8)) and human malignancy. KSHV has a causative role in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease, an aggressive lymphoproliferative disorder. KSHV latently infects tumor cells and persists as a multi copy, extrachromosomal episome. The goal of his team is to gain a better understanding of the molecular mechanisms underlying KSHV pathogenesis. Dr. Kaye’s group is investigating the molecular mechanism of action of the KSHV protein, LANA, which is essential for virus survival and persistence in tumor cells. A better understanding of LANA’s function may lead to strategies to treat or prevent KSHV tumors.