My research program is aimed at understanding biology of the flagellum (synonymous with cilium) and cell-cell communication in the African trypanosome Trypanosoma brucei (http:,,www.mimg.ucla.edu,faculty,hill,). These devastating pathogens cause substantial human mortality and pose an economic burden in some of the world’s most impoverished regions. The flagellum drives parasite motility and cell morphogenesis and provides a platform for signaling and host-parasite interaction. The motivations of our studies are two-fold. Firstly, we study the flagellum’s contribution to parasite development, transmission and pathogenesis. These efforts have illuminated important features of trypanosome biology, provided paradigms for host-pathogen interaction and identified candidate therapeutic targets. Secondly, we develop and exploit trypanosomes as a powerful system for investigating cilium biology, illuminating mechanisms underlying the cilium’s role in human health and disease.