Department of Molecular and Human Genetics
Baylor College of Medicine
Mail Stop BCM 225
One Baylor Plaza, Room S911
Houston, TX 77030
TOPICS AND DESCRIPTIONS
Prevention of Conflict Between Replication and Transcription
DNA replication and transcription occupy the same DNA template and their conflict can have strong impact on cellular fitness and evolution. This lecture will address how bacterial cells prevent or resolve this conflict via different mechanisms to maintain genome integrity, and how this conflict shapes genome organization.
The Interface Between Replication Elongation and its Cellular Environment
Accurate DNA replication is essential for the survival and fitness of all organisms. The interface between DNA replication and other cellular processes is essential for replication to respond readily to metabolic and external cues, and for cells to monitor the replication status and respond accordingly. Because replication mechanisms are conserved across all of life, work in bacteria is a broadly applicable model.
Post-Genomic Insights into the Alarmone and Genome StabilityThe alarmone (p)ppGpp is ubiquitously present in bacteria and is crucial for their survival and virulence. This lecture will discuss new insights obtained about how (p)ppGpp is regulated in the Gram-positive bacterium B. subtilis and how it ensures the survival of bacteria during nutrient stress, taking advantage of new genomic approaches.
Dr. Jue (“Jade”) Wang is an Assistant Professor in the Departments of Molecular and Human Genetics, Biochemistry and Molecular Biology, and Molecular Virology and Microbiology at Baylor College of Medicine, and a Co-Director of the Interdepartmental Graduate Program in Cellular and Molecular Biology. She graduated with a B.Sc degree in physics from McGill University in Canada. Her Ph.D. in biochemistry, which focused on the mechanisms of action of molecular chaperones, was in Jonathan Weissman’s laboratory at the University of California, San Francisco (UCSF) in collaboration with Carol Gross. She became a microbiologist and genomicist during her postdoc with Alan Grossman at the Massachusetts Institute of Technology (MIT). Dr. Wang’s lab currently focuses on control of bacterial DNA replication by nutritional availability, the conflicts between replication and transcription and the mechanism by which they are resolved, and genome organization and replication stress in B. subtilis and E. coli. She is a recipient of an NIH Director’s New Innovator Award (2008-2013) and a winner of the 2010 Rosalind Franklin Young Investigator Award by the Genetics Society of America and the Peter and Patricia Gruber Foundation.
ASM MEMBERSHIP AFFILIATION
Primary Division H Genetics & Molecular Biology
Secondary Division K Microbial Physiology & Metabolism