Clinical Microbiology Issues Update - May 2015

PSAB ACTIVITIES

  • PSAB Sponsors Federal Funding Opportunities Breakfast at asm2015
  • ASM Comments on the 21st Century Cures Act
  • FDA Invites ASM to Assist in Drafting Duodenoscope Culture Standards
  • Minority Microbiology Mentor Newsletter

ASM NEWS, JOURNAL ARTICLES AND UPDATES

  • ASM 2015 Clinical Highlights
  • Clinical Microbiology Portal Q & A
  • ASM Conferences
  • ASM Journal Articles of Interest
  • ASM Press
  • Articles of Interest

FEDERAL AGENCY UPDATES

  • New and Reconsidered Clinical Diagnostic Laboratory Test Codes for the CLFS for CY 2016
  • FDA Proposes Rule to Address Data Gaps for Active Ingredients in Health Care Antiseptics
  • FDA Approves Additional Antibacterial Treatment for Plague
  • CDC Data Show Progress in Reducing Some Foodborne Infections in 2014
  • NIAID Promotes HIV Vaccine Awareness Day
  • MMWR Articles of Interest

OTHER INFORMATION AND UPDATES

  • ASCLS Annual Meeting, AMI and Exposition
  • Webinar: Utilization Management in Medical Microbiology
  • ASCP 2015: Beyond the Lab
  • Articles of Interest

 

PSAB ACTIVITIES

PSAB Sponsors Federal Funding Opportunities Breakfast at asm2015
The Public and Scientific Affairs Board will sponsor a Federal Funding Opportunities Breakfast at asm2015 in New Orleans, LA on Monday, June 1 at 8:00 a.m. in the Ernest N. Morial Convention Center, Meeting Room 242.  Speakers will offer updated information about funding opportunities from several federal agencies.

ASM Comments on the 21st Century Cures Act
The ASM sent comments to the Chair and Ranking Member of House Committee on Energy and Commerce on the 21st Century Cures Initiative.  This comprehensive legislation aims to stimulate both innovation in biomedical research and the development of new medical treatments and cures.  To see the letter, go to http://www.asm.org/index.php/public-policy-2/137-policy/documents/statements-and-testimony/93512-cures-5-8

FDA Invites ASM to Assist in Drafting Duodenoscope Culture Standards
The Food and Drug Administration (FDA) identified several outbreaks of infections with antibiotic resistant bacteria that were traced to improperly processed endoscopes. FDA reached out to ASM after the PSAB Laboratory Practices Committee produced “On Culturing of Duodeoscopes” (http://www.asm.org/index.php/public-policy-2/98-policy/issues/93456-lp-4-15). ASM staff attended the FDA Gastroenterology and Urology Devices Panel of the Medical Devices Advisory Committee Meeting (http://www.fda.gov/AdvisoryCommittees/Calendar/ucm437500.htm) and ASM is currently working with the FDA by providing expert volunteers to assist with development of a protocol for validation of an endoscope culturing method. 

Minority Microbiology Mentor Newsletter
The May 2015 issue of the Minority Microbiology Newsletter has just been published by the Committee on Microbiological Issues Impacting Minorities (CMIIM).  You can read the newsletter by going to this link: http://www.asm.org/index.php/public-policy-2/135-policy/documents/newsletters/minority-microbiology-mentor-newsletter/93517-mmm-5-15.   

ASM NEWS, JOURNAL ARTICLES AND UPDATES

ASM 2015 Clinical Highlights
The ASM2013 Online Program Planner allows you to search or browse presentations or sessions, create your own personalized itinerary and download it to your online mobile device. To access the planner, please go to http://gm.asm.org/ and access the Online Program Planner.

Several PSAB sponsored sessions will be held on two days.  On Sunday May 31, from 4:45 to 6:30 pm:

  • Committee on Microbiological Issues Impacting Minorities Session: Immunology Issues and Infection in Hemoglobinopathy Populations with Health Disparities in the Ernest N. Morial Convention Center (MCCNO) Room 346.
  • Late Breaker Special Interest Session - Duodenoscope Associated Superbug Outbreaks: What your Lab Needs to Know! in MCCNO Room 356. ASCLS P.A.C.E.® credit eligible.
  • Committee on the Status of Women in MicrobiologySession: Contributions to “Extreme” Microbiology by Female Scientistsin MCCNO Room 355

On Monday, June 1, from 4:45 to 6:30 pm:

  • Laboratory Professionals Committee Special: Implementing IQCP in Your Laboratory in MCCNO Room 343. ASCLS P.A.C.E.® credit eligible
  • Professional Affairs Committee Session: Making Your Presence Known in MCCNO Room 339. ASCLS P.A.C.E.® credit eligible.

Division Lectures will be held as follows:

  • Division C: Clinical Microbiology Laboratory Safety in the Age of Automation. Sunday, May 31, 8:00 a.m. - 10:30 a.m.
  • Division V: Diagnostic Challenges of Arboviruses. Monday, June 1, 2:00 p.m. - 4:30 p.m.
  • Division Y: Think Global, Act Local! Tuesday, June 2, 8:00 a.m. - 10:30 a.m.

Clinical Microbiology Portal Q & A
ASM members can submit questions to the Clinical Microbiology Portal for an expert's response and search an existing database of questions that have already been answered.  To see these, go to https://clinmicro.asm.org/index.php/component/content/article?id=417:question-and-answer.  

ASM Conferences

5th ASM Conference on Prokaryotic Cell Biology and Development
June 12-16, 2015
Washington, DC

ASM Conference on Pseudomonas 2015
September 8-12, 2015
Washington, DC

1st ASM Conference on Rapid Next-Generation Sequencing and Bioinformatic Pipelines for Enhanced Molecular Epidemiologic Investigation of Pathogens
September 24-27, 2015
Washington, DC

For a complete list of upcoming ASM conferences, please see http://conferences.asm.org/.

ASM Journal Articles of Interest

Phage Spreads Antibiotic Resistance
Investigators found that nearly half of the 50 chicken meat samples purchased from supermarkets, street markets, and butchers in Austria contained viruses that are capable of transferring antibiotic resistance genes from one bacterium to another. This research is published in Applied and Environmental Microbiology and more information is at http://www.asm.org/index.php/asm-newsroom2/press-releases/92-news-room/press-releases/93520-phage-spread-antibiotic-resistance.

Bacterial Microcompartments: Applications May Include Renewable Chemicals, Drug Delivery, Novel Antimicrobials
Bacteria contain “microcompartments,” which are poorly understood organelles that play critical roles in metabolism. Understanding how they work may ultimately enable engineering them for useful applications. Thomas Bobik, PhD, and collaborators shed new light on how microcompartments work. The research is published in the Journal of Bacteriology.  To read more, go to http://www.asm.org/index.php/asm-newsroom2/press-releases/92-news-room/press-releases/93514-new-light-on-bacterial-microcompartments-ultimate-applications-may-include-renewable-chemicals-drug-delivery-novel-antimicrobials.  

Fecal Microbiota Transplant Cures C. difficile Infection, Blocks Multi-Drug Resistant Pathogens
A fecal microbiota transplant (FMT) both cured a case of Clostridium difficile infection in elderly man and eliminated populations of multi-drug resistant organisms both in the gastrointestinal tract, and at several other body sites. This case report is published ahead of print April 15 in the Journal of Clinical Microbiology.  More information can be found at http://www.asm.org/index.php/asm-newsroom2/press-releases/92-news-room/press-releases/93497-fecal-microbiota-transplant-cures-c-diff-blocks-multi-drug-resistant-pathogens.  

ASM Press

Manual of Clinical Microbiology, 11th Edition
Editors:  James H. Jorgensen and Michael A. Pfaller
Two-Volume Hardcover Set, 2,900 pages (est), full-color illustrations, index.
(ISBN: 9781555817374)  For more information, please visit the e-store at:
http://www.asmscience.org/content/book/10.1128/9781555817381.

Enterohemorrhagic Escherichia coli and Other Shiga Toxin-Producing E. coli
Editors:  Vanessa Sperandio and Carolyn J. Hovde
Hardcover, 550 pages (est), full-color illustrations, index.
(ISBN: 9781555818784) For more information, please visit the e-store at:
http://www.asmscience.org/content/book/10.1128/9781555818791.

Zoonoses: Infectious Diseases Transmissible between Animals and Humans, 4th Edition
Authors:  Rolf Bauerfeind, Alexander von Graevenitz, Peter Kimmig, Hans Gerd Schiefer, Tino Schwarz, Werner Slenczka, Horst Zahner
Paperback, 575 pages (est), full-color illustrations, index.
(ISBN: 9781555819255)  For more information, please visit the e-store at:
http://www.asmscience.org/content/book/10.1128/9781555819262

Articles of Interest

Active Tracing and Monitoring of Contacts Associated With the First Cluster of Ebola in the United States
Following hospitalization of the first patient with Ebola diagnosed in the United States on 28 September 2014, contact tracing methods for Ebola were implemented. The objective was to identify risk-stratify, and monitor contacts of patients with Ebola in Dallas County, Texas. 

Isolation and Antibiotic Susceptibility Patterns of Shigella and Salmonella among Under 5 Children with Acute Diarrhoea
Diarrhoeal illness remains one of the leading causes of morbidity and mortality among children<5 years of age worldwide. In Ethiopia, Shigella and Salmonella are major causes of gastroenteritis associated with high resistance levels. The aim of this study was to isolate and determine susceptibility patterns of Shigella and Salmonella, isolated from childrenwith diarrhoea attending selected health facilities in Addis Ababa, Ethiopia.

FEDERAL AGENCY UPDATES

New and Reconsidered Clinical Diagnostic Laboratory Test Codes for the CLFS for CY 2016
The Centers for Medicare & Medicaid Service have scheduled the annual public meeting discussing new and reconsidered clinical diagnostic laboratory test codes for the clinical laboratory fee schedule for calendar year 2016.  The meeting is scheduled for Thursday, July 16, 2015 from 9:00 a.m. to 3:00 p.m. in Baltimore, MD.  To submit comments or register, please go to http://www.gpo.gov/fdsys/pkg/FR-2015-05-07/pdf/2015-11026.pdf.

FDA Proposes Rule to Address Data Gaps for Active Ingredients in Health Care Antiseptics
The U.S. Food and Drug Administration issued a proposed rule requesting additional scientific data to support the safety and effectiveness of certain active ingredients used in health care antiseptics.  Health care antiseptics are primarily used by health care professionals in hospitals, clinics, doctors’ offices, outpatient settings and nursing homes. Based on new scientific information and concerns expressed by outside scientific and medical experts on an FDA advisory committee, the agency is requesting additional scientific data to demonstrate that health care antiseptics in the over-the-counter drug monograph are generally recognized as safe and effective (GRASE) for their intended use to reduce pathogenic bacteria.  To read more, please go to http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm445002.htm.

FDA Approves Additional Antibacterial Treatment for Plague
The U.S. Food and Drug Administration recently approved Avelox (moxifloxacin) to treat patients with plague. The agency approval for plague includes use of the drug for the treatment of pneumonic plague and septicemic plague. Avelox is also approved for prevention of plague in adult patients.  To learn more about Avelox, go to http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm446283.htm.

CDC Data Show Progress in Reducing Some Foodborne Infections in 2014
In 2014, rates of infection from a serious form of E. coli and one of the more common Salmonella serotypes decreased compared with the baseline period of 2006-2008. Meanwhile, some other less common types of Salmonella increased. Campylobacter and Vibrio rose again in 2014, continuing the increase observed during the past few years, according to data published by the Centers for Disease Control and Prevention (CDC).  To read more, see http://www.cdc.gov/media/releases/2015/p0514-reducing-foodborne-infections.html.

NIAID Promotes HIV Vaccine Awareness Day
The National Institute of Allergy and Infectious Disease (NIAID) promoted HIV Vaccine Awareness Day on May 18.  Although the path to developing a safe and effective HIV vaccine has so far been difficult, achieving this goal remains key to realizing a durable end to the global HIV/AIDS pandemic.  To read more about NIAID’s efforts on HIV vaccine development, go to http://www.niaid.nih.gov/news/newsreleases/2015/Pages/HVAD2015.aspx

MMWR Articles of Interest

Possible Sexual Transmission of Ebola Virus: Liberia, 2015
On March 20, 2015, 30 days after the most recent confirmed Ebola Virus Disease patient in Liberia was isolated, Ebola was laboratory confirmed in a woman in Monrovia. The investigation identified only one epidemiologic link to Ebola: unprotected intercourse with a survivor. Published reports from previous outbreaks have demonstrated Ebola survivors can continue to harbor virus in immunologically privileged sites for a period of time after convalescence.

Norovirus Outbreak Associated with a Natural Lake Used for Recreation
In July 2014, Multnomah County public health officials investigated a norovirus outbreak among persons visiting Blue Lake Regional Park in Oregon. During the weekend of the reported illnesses (Friday, July 11 through Sunday, July 13) approximately 15,400 persons visited the park. The investigation identified 65 probable and five laboratory-confirmed cases of norovirus infection (70 total cases).

Lyme Disease Awareness Month: May 2015
To assist health care providers in diagnosing and treating Lyme disease and other tick-borne diseases, CDC has released the booklet “Tickborne Diseases of the United States: A Reference Guide for Health Care Providers” and a corresponding cellular telephone and tablet application. In addition, free continuing education credits are available. 

OTHER INFORMATION AND UPDATES

ASCLS Annual Meeting, AMI and Exposition
Atlanta, GA
July 26 – August 1, 2015
Attend the 83rd meeting of the American Society for Clinical Laboratory Science
http://www.ascls.org/ascls-meetings/annual-meeting-new

Webinar: Utilization Management in Medical Microbiology
Join AACC for this 60-minute webinar and learn how one organization manages test utilization in today’s dynamic microbiology testing environment.
SPEAKER: John Branda, MD, Assist. Pathologist and Assoc. Director, Microbiology Laboratory, Mass. General Hospital
Read more at https://www.aacc.org/store/webinars/9700/utilization-management-in-medical-microbiology

ASCP 2015: Beyond the Lab
Long Beach, CA
October 28-30, 2015
See http://www.ascp.org/ascp2015 for information.

Articles of Interest

New Jersey Lassa Fever Death Prompts C.D.C. Action
New York Times
May 27, 2015
A six-member team from the Centers for Disease Control and Prevention arrived in New Jersey on Tuesday morning and was overseeing work at the hospitals where the man was seen, including helping hospital officials identify which, if any, health care workers should be monitored for symptoms.

Man in New Jersey Dies of Rare Viral Disease after Returning From Liberia
New York Times
May 26, 2015
A man died of Lassa fever at a hospital in New Jersey on Monday after returning from Liberia this month, health authorities announced.  The patient, who was not identified, traveled from Liberia to Morocco and arrived at John F. Kennedy International Airport on May 17. The patient did not have a fever on departure from Liberia, or any symptoms such as bleeding, diarrhea or vomiting when he arrived in the United States.

Scientists Are Using Herpes to Treat Skin Cancer - And It’s Working
Washington Post
May 26, 2015
A modified version of the Herpes Simplex 1 virus called T-Vec has successfully been used to treat melanoma in a phase III clinical trial. T-VEC starts with the herpes virus, which is magnificent at proliferating itself within cells and then causing them to burst.  But T-VEC has had two key genes removed, which keeps it from replicating within healthy cells.

House Panel Seeks Expanded GAO Review of Smallpox Incident at NIH
Washington Post
May 19, 2015
In a letter, Rep. Fred Upton (R-Mich.), who chairs the House Energy and Commerce Committee, and Rep. Tim Murphy (R-Pa.), who chairs its oversight subcommittee, said the smallpox inspection reports raise new questions. They asked that the Government Accountability Office expand its review of the handling of biological agents and toxins by federal laboratories.

FDA Proposes to Know More about Antibiotic Use in Animals
Washington Post
May 19, 2015
The Food and Drug Administration is moving to collect more information on antibiotics used in animals that become meat in an effort to stem antibiotic-resistant diseases.  The proposed rule would require drug companies to collect sales information broken down by which animals are using the antibiotics. That would expand current law that now requires companies to report the overall volume they sell annually for use in food-producing animals.

FDA Regulation of Diagnostic Tests: One Step Forward, Two Steps Back
Forbes
May 6, 2015
Reversing past policy, FDA will begin to regulate a class of products called “laboratory-developed tests” (LDTs), sometimes called “home-brew” tests because they are developed in and used in a single clinical laboratory rather than being manufactured and sold by big companies.

TPL_asm2013_SEARCH

93535:cmiu-5-15