Stephen Lory

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(Speaker Term: July 1, 2014 - June 30, 2016)


Stephen Lory (term: 7/1/14 through 6/30/16)

Department of Microbiology and Immunobiology

Harvard Medical School

77 Avenue Louis Pasteur

Boston, MA  02115                                                


Phone:  617-432-5099

Fax:  617-738-7664




Primary Division:  B (Microbial Pathogens)      



Pseudomonas aeruginosa Genome Evolution 

(For specific information on this lecture, please contact Stephen Lory at


Regulation of Gene Expression in Opportunistic Pathogens

(For specific information on this lecture, please contact Stephen Lory at


Exploitation of -omics Approaches to Identify Fitness Traits in P. aeruginosa

(For specific information on this lecture, please contact Stephen Lory at   



Dr. Lory has spent his entire scientific career studying Pseudomonas aeruginosa, a bacterium widely distributed in the environment and an important human pathogen.  His work as a graduate student at UCLA focused on comparison of toxins produced by this organism to other related toxic proteins.  While a post-doctoral fellow at Harvard, he studied secretion of protein toxins from P. aeruginosa, a project he continued in his laboratory at the University of Washington, leading to the discovery of the type II secretion system.  Here he also became interested in microbial genomics, and participated in a project that resulted in the sequencing of the first P. aeruginosa.   He developed the first microarray for P. aeruginosa allowing investigators to define its transcriptome in a wide range of environments.  After moving to Harvard in 2000, he was one of the early investigators in the field of cyclic nucleotide signaling.  His current work exploits deep sequencing as a tool for understanding bacterial evolution and the role of small regulatory RNAs in regulation of gene expression.  He is active as a manuscript and grant reviewer for the NIH and Cystic Fibrosis Foundation and has published one textbook and over 110 papers in peer-reviewed journals.  


CV is available by request from at ASM Headquarters 



I am greatly honored to be selected for the American Society for Microbiology Distinguished Lecturer (ASMDL) Program.  I have spent all of my scientific life, starting as an undergraduate laboratory volunteer (when I first joined the ASM) to my current position as a Professor at a research university, studying bacteria; in my opinion, the most fascinating living creatures.  Since graduate school, my work has centered on the studies of physiology, genetics and virulence of the opportunistic pathogen Pseudomonas aeruginosa.  Although I have been meeting fellow microbiologists at national and international meetings, the ASMDL program will give me an opportunity to more closely observe the daily activities of students, scientists and educators in a different setting, at their home colleges and universities.  I anticipate having great learning experiences, particularly in settings where one can exchange informal ideas on a wide range of topics ranging from untested scientific hypotheses to the developing of new concepts and technologies.  I am also eager to exchange ideas about the educational experience of the various ASM Branch microbiologists, brainstorming about the most effective ways of communicating the excitement of our field not only to potential scientists or physicians but also to the lay public.  Through the ASMDL program, I hope to bring to the Branches interesting research findings from my laboratory as well as present projects under development.  I am excited about the possibilities of establishing new collaborations that would facilitate both my own research as well as the work in the laboratories of the Branch members I encounter during my visits.     


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