http://www.asm.org/modules/mod_image_show_gk4/cache/mSphere Direct herogk-is-651.pnglink
http://www.asm.org/modules/mod_image_show_gk4/cache/Podcast Hero Banner3gk-is-651.pnglink
http://www.asm.org/modules/mod_image_show_gk4/cache/Microbe Online Program Plannergk-is-651.pnglink
http://www.asm.org/modules/mod_image_show_gk4/cache/AAAS Fellows Bannergk-is-651.jpglink
http://www.asm.org/modules/mod_image_show_gk4/cache/Read New JMBE Bannergk-is-651.jpglink
0 1 2 3 4
Progress bar
21-01-2017mSphere Direct
21-01-2017Podcast banner
21-01-2017AAAS Fellows
21-01-2017Read new JMBE
Become a member today!
JOIN/RENEW
Submit to an ASM Journal
SUBMIT
Attend ASM Biothreats Meeting
REGISTER

baric ralph

 

The Baric laboratory uses genetic, immunologic and biochemical approaches to study the molecular mechanisms regulating viral replication, pathogenesis, evolution, virus-host interactions and cross species transmission using coronaviruses and noroviruses as model systems. They also deconstruct the fundamental viral/host genetic and pathogenic pathways that modulate virulence in vivo using young and aged models of human disease. One outcome is to harness unique biological processes encoded in viral genomes as tools for developing safe efficacious vaccines and/or vector platforms for the treatment of human diseases. Laboratory expertise includes virus reverse genetic approaches for several positive strand RNA viruses, phylogenetic and structural modeling of virus-receptor interactions, functional genomics and next gen sequencing, and evolutionary genetic approaches to understand virus persistence and pathogenic mechanisms in human populations. The laboratory has a particular interest and tract record in using synthetic genomics to manipulate viral genomes and reconstruct noncultivatable viruses from in silica sequence information sources, including the synthetic reconstruction of the largest RNA virus genome to date from in silica sequence signatures; a platform to ask fundamental questions into virus emergence and disease.

TPL_asm2013_SEARCH

91001