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Prof. Kupiec’s laboratory research is focused on the mechanisms that keep the genome stable. He uses the yeast Saccharomyces cerevisiae as a model organism to ask questions about DNA repair and maintenance mechanisms, using a combination of “vertical” (Molecular Biology) and “horizontal” (Systems Biology) approaches. Among the various questions studied in the lab are: how do cells cope with broken chromosomes, or with lesions that appear during DNA replication? How do cells maintain their telomere length? What prevents rearrangements due to recombination between repeated sequences? How are cell cycle progression and repair coordinated?