Dr. Ou’s research interest is to understand the life cycle of hepatitis B virus (HBV) and hepatitis C virus (HCV) and their pathogenesis. He has made major research contributions toward understanding the molecular mechanisms that regulate gene expression of these two viruses. He has also made seminal findings on viral gene functions and elucidated the mechanism of hepatocellular carcinogenesis induced by these two viruses. More recently, he discovered that both HBV and HCV could perturb the cellular autophagic pathway and use it to enhance their replication. This finding has important implications in the pathogenesis of these two viruses.