Dr. Su's laboratory develops and uses genome-wide approaches to study mechanisms of drug resistance, virulence, genome diversity, population genetics, and evolution of malaria parasites. Large numbers of parasite isolates and progeny from genetic crosses are being typed using thousands of single nucleotide polymorphisms (SNPs), and the genotypes are being associated or linked to differences in parasite response to large numbers of chemical compounds and drugs. Dr. Su also uses the rodent malaria parasite Plasmodium yoelii as a model to study virulence factors and disease phenotypes. He has developed a microsatellite genetic map and performed several genetic crosses to identify genes associated with parasite growth, virulence and drug resistance. Other projects include nucleosome position mapping and gene expression regulation, recombination hotspots and conserved motifs that may play a role in genetic recombination, and the roles of ABC transporters in drug resistance.