Roger J. Davis Ph.D. F.R.S. is an Investigator of the Howard Hughes Medical Institute and is the H. Arthur Smith Chair in the Program in Molecular Medicine at the University of Massachusetts Medical School. He also serves as Editor-in-Chief of the ASM journal Molecular & Cellular Biology. The goal of research in the Davis laboratory is to understand mechanisms that mediate inflammation. A primary focus is to understand the function of protein kinase signaling networks that promote inflammation, including the stress-activated MAP kinases. These signaling pathways respond to the exposure to inflammatory agents (e.g. endotoxin) and mediate multiple biological responses. The stress-activated MAP kinases are implicated in both innate and adaptive immune response and contribute to the development of inflammation-related diseases, including arthritis, cancer, diabetes, heart disease, and stroke. The Davis laboratory is exploring the potential use of drugs to manipulate these signaling pathways for the treatment of human disease.