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Dr. Heyer’s research focuses on how cells maintain genomic integrity and employ homologous recombination to repair and tolerate DNA damage as well as to recover stalled and broken replication forks. His laboratory combines genetic and biochemical approaches to elucidate the mechanisms and regulation of recombination using the budding yeast Saccharomyces cerevisiae as a lead model. Parallel studies with human proteins and human cells validate the paradigms established in the yeast and analyze genes/proteins, such as BRCA2, not present in yeast. In combination with mathematical pathway modeling, his laboratory is also interested in applying the mechanistic insights to cancer biology and anti-cancer treatment.