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Dr. Kenneth Tyler's clinical interests include the study of infections of the Central Nervous System (CNS) generally, with a particular emphasis on neurovirology. His laboratory studies virus-host interactions with a focus on understanding mechanisms of virus-induced cell death and tissue injury. These studies involve identification of host-cell signaling and transcription pathways perturbed during viral infections and utilizes models ranging from primary and continuous cell cultures to organotypic slices to whole animal models. His lab is interested in identifying key processes that are triggered during viral infection that lead to cell death and associated tissue injury in the central nervous system. The goal is to identify potentially novel targets for antiviral therapy and to enhance neuroprotection during viral CNS infection.