2. DTBE Immunology and Cell biology of Mycobacterium tuberculosis Infections and Development of New Generation Vaccines
S. B. Sable
Development and evaluation of new generation prophylactic, post-exposure and therapeutic vaccines is urgently needed for the effective control of global tuberculosis pandemic. The current and proposed focus areas of immunology activity include:1. Development of new generation mucosal vaccine against tuberculosis; 2. Evaluation of quality and magnitude of local T-cell response and identification of correlates of protection in the lungs; and 3. Protective efficacy of BCG and second generation vaccines against different M. tuberculosis families/clades prevalent in different parts of the world.
Sable SB, Plikaytis BB, Shinnick TM. Tuberculosis Subunit Vaccine Development: Impact of Physicochemical Properties of Mycobacterial Test Antigens. Vaccine. 2007 Feb 19; 25(9):1553-66.
Sable SB, Kalra M, Verma I, Khuller GK. Tuberculosis subunit vaccine design and the conflict of antigenicity and immunogenicity. Clin. Immunol. 2007 Mar; 122(3):239-51.