Full Scientific Program

Sunday, May 31	Session I: It All Starts with DNA Repair Chair: Priscilla K. Cooper
8:30 am – 8:40 am	Welcome
	Graham C. Walker, Massachusetts Institute of Technology

8:40 am – 8:45 am	Introduction of Keynote Address
	Priscilla K. Cooper, Lawrence Berkeley National Laboratory

8:45 am – 9:30 am	Keynote Address - Meandering through the Maze of Oxidative DNA Damage
	Susan S. Wallace, University of Vermont

9:30 am – 9:55 am	Mechanisms of Genomic Instability During Base Excision Repair
	Samuel H. Wilson, , National Institute of Environmental Health Sciences. NIH

9:55 am – 10:20 am	Subpathways for Oxidative Damage Repair in the Mitochondrial Genome
	Sankar Mitra, University of Texas Medical Branch

10:20 am – 10:50 am	Coffee Break

	*The following talks were selected from the abstracts:*

10:50 am – 11:05 am	Structural Illumination of a MutY Glycosylase Reaction Coordinate Intermediate
	Sheila S. David, University of California

11:05 am – 11:20 am	Structure and DNA Binding of Alkylation Response Protein AidB
	Brandt F. Eichman, Vanderbilt University

11:20 am – 11:35 am	Thymine DNA Glycosylase is Required for Embryonic Development and DNA Demethylation in Mammals
	Alfonso Bellacosa, Fox Chase Cancer Center

11:35 am – 11:50 am	Arabidopsis ROS1 is a Non-Processive 5-methylcytosine DNA Glycosylase that Initiates Demethylation through an AP Endonuclease-Independent Excision Pathway
	Teresa Roldan-Arjona, University of Cordoba

11:50 am – 12:05 pm	The Role of MutS and MutL in Very Short Patch Repair in Escherichia coli.
	Claire G. Cupples, University of Victoria

12:05 pm – 12:20 pm	Functional Redundancy and Uniqueness Among the Human RecQ Helicases
	Raymond Monnat, University of Washington

	Session II: Locating Lesions and Coordinating Repair
	Chair: Leon H. Mullenders

4:00 pm – 4:25 pm	Intersecting DNA Repair Pathways and Coordination with Transcription and Replication
	Priscilla K. Cooper, Lawrence Berkeley National Laboratory

4:25 pm - 4:50 pm	DNA Damage, Transcription Stalling and Cellular Responses
	Leon H. Mullenders, Leiden University Medical Center

4:50 pm – 5:15 pm	UV-Induced DNA Damage Response in Mammalian Cells
	Wim Vermeulen, Erasmus Medical Center

	The following talks were selected from the abstracts:

5:15 pm – 5: 30 pm	Dynamic Damage Searching by Nucleotide Excision Repair Proteins Investigated by Single-Molecule Fluorescence of Quantum Dot Labeled Proteins
	Ben Van Houten, University of Pittsburgh

5:30 pm – 5:45 pm	Molecular Basis of Multistep Damage Recognition in Mammalian Nucleotide Excision Repair
	Kaoru Sugasawa, Kobe University

5:45 pm – 6:00 pm	Structural and Functional Studies on the FeS Cluster Containing Nucleotide Excision Repair Helicase XPD
	Caroline Kisker, University of Wuerzburg

6:00 pm – 6:15 pm	Replisome Bypass of a Head-on RNA Polymerase is Facilitated by the Transcription- Coupled Repair Helicase Mfd
	Richard T. Pomerantz, Rockefeller University

6:15 pm – 6:30 pm	Transcription-Coupled Gene Amplification in E. coli: Is Adaptive Amplification Targeted to Specific Areas of the Genome in Response to Stress?
	Hallie Wimberly, Baylor College of Medicine

Monday, June 1
	Session III: Cellular Responses to DNA Damage
	Chair: Daniel Durocher

8:30 am – 8:35 am	Introduction of Keynote Address
	Peggy Hsieh, National Institute of Diabetes and Digestive and Kidney Diseases, NIH

8:35 am – 9:20 am	Cellular Responses to DNA Double-Strand Breaks
	Stephen P. Jackson, The Wellcome Trust and Cancer Research UK, The Gurdon Institute, University of Cambridge, UK

9:20 am - 9:45 am	A Systems Biology Approach to DNA Damage Signaling
	Michael B. Yaffe, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology

9:45 am – 10:10 am	ATM Signalling Relieves the Constraints to Double Strand Break Repair Caused by Higher order Chromatin Structure
	Penelope A. Jeggo, University of Sussex, UK

10:10 am - 10:40 am	Coffee Break

10:40 am – 11:05 am	Regulatory Ubiquitylation at sites of DNA Double-Strand Breaks: From RNAi Screening to Human Disease
	Daniel Durocher, Samuel Lunenfeld Research Institute, Mount Sinai Hospital

11:05 am – 11:30 am	DNA Damage Signaling: Mechanisms and Role in Human Tumorigenesis and Treatment Response
	Jiri Bartek, Danish Cancer Society

	*The following talks were selected from the abstracts:*

11:30 am – 11:45 am	The ATM Protein Displays Distinct Spatial Dynamics at the Sites of DNA damage
	Paul S. Bradshaw, The Hospital for Sick Children

11:45 am - 12:00 pm	MicroRNA-Mediated Gene Silencing, a Novel Level of DNA Damage Response Regulation
	Joris Pothof, Erasmus University Medical Center

12:00 pm – 12:15 pm	A New Member of Genes, Mapo1, Involve in O⁶-Methylguanine Induced Apoptosis
	Masumi Hidaka, Fukuoka Dental College

12:15 pm – 12:30 pm	Cooperation between ATR/ATM and PolZeta/PolEta Pathways in Replication- StressedTissue Stem-Cell Niches
	John B. Hays, Oregon State University

	Session IV: Mutation and Mutagenesis
	Chair: Roger Woodgate

4:00 pm – 4:25 pm	Investigating the Mechansims of Spontaneous and Damage Induced Mutagenesis in Escherichia coli
	Roger Woodgate, Laboratory of Genomic Integrity, National Instituteof Child Health and Human Development, NIH, USA

4:25 pm – 4:50 pm	Transcriptional Mutagenesis by 8-oxoguanine causes Ras Activation in Mammalian Cells
	Paul W. Doetsch, Emory University School of Medicine

4:50 pm – 5:15 pm	Balancing AID and DNA Repair During Somatic Hypermutation of Immunoglobulin Genes
	David G. Schatz, Yale University School of Medicine

	*The following talks were selected from the abstracts:*

5:15 pm – 5:30 pm	Biochemistry of DNA-cytosine Deaminases Required for Antibody Maturation and Retrovirus Restriction
	Ashok Bhagwat, Wayne State University

5:30 pm – 5:45 pm	Damage-Induced Localized Hypermutability
	Dmitry A. Gordenin, Natinal Institute of Environmental Health Sciences, NIH

5:45 pm – 6:00 pm	Error-Prone DNA Polymerase IV (DinB) and the Universal Stress-Responses of Escherichia coli
	Patricia L. Foster, Indiana University

6:00pm – 6:15 pm	Nuclear Reorganization of DNA Mismatch Repair Proteins in Response to DNA Damage
	Chris Heinen, University of Connecticut Health Center
Tuesday, June 2

	Session V: Unusual DNA Structures, Chromatin and DNA Repair
	Chair: Titia de Lange

8:30 am – 8:55 am	Unusual DNA Structures and Genetic Instability
	Karen Vasquez, University of Texas M.D. Anderson Cancer Center,

8:55 am – 9:20 am	Yet another Telomere Replication Problem
	Titia de Lange, Rockefeller University

9:20 am – 9:45	The Role of the RSC Chromatin Remodeling Complex in DNA Double Strand Break Repair
	Jessica A. Downs, University of Sussex

	*The following talks were selected from the abstracts:*

9:45 am - 10:00 am	Mechanistic Links between Tip60, ATM and Histone Methylation Codes During DNA Repair
	Brendan D. Price, Dana-Farber Cancer Institute

10:00 am – 10: 15 am	A Histone Code for NHEJ Repair Mediates Chemotherapy Resistance
	Robert Hromas, University of New Mexico Cancer Center

10:15 am – 10:45 am	Coffee Break

10:45 am – 11: 00 am	Genetic Dissection of The Mechanisms Underlying Telomere Associated Diseases: Impact of The TRF2 Telomeric Protein on Mouse Epidermal Stem Cells
	Gerdine J. Stout, Spanish National Cancer Research Center

11:00 am – 11:15 am	Transcriptional Processing of Non-Canonical DNA Structures
	Philip C. Hanawalt, Stanford University

11:15 am – 11:30 am	Incision-Dependent and Error-Free Repair of CAG/CTG Hairpins in Human Cells
	Guo-Min Li, University of Kentucky

11:30 am – 11:45 am	Nucleosome Remodeling Catalyzed by the Human hMSH2-hMSH6 Mismatch Recognition Complex
	Sarah Javaid, The Ohio State University

11:45 am – 12:00 pm	Interactions of MutY Homolog (MYH) with Checkpoint Sensor Hus1/Rad1/Rad9 and Histone Deacetylase Hst4 in Fission Yeast, Schizosaccharomyces pombe
	A-Lien Lu-Chang, University of Maryland

12:00 pm – 12:15 pm	Increased Reliance On DNA Repair In Malignant Gliomas With Hyperactive EGFR: A Proof of Principle In Targeting Non-Oncogene Addiction
	Clark C. Chen, Dana Farber Cancer Institute

12:15 pm – 12:30 pm	MRE11 Cleaves Topoisomerase 1-DNA Covalent Complexes to Promote Resistance to Camptothecin
	Elizabeth J. Sacho, University of Washington

	Session VI: Aging, Cancer and Human Disease Chair: Richard D. Wood
4:00 pm - 4:25 pm	DNA Damage, Cancer, Aging and the Survival Response that Promotes Longevity
	Jan H.J. Hoeijmakers, Erasmus University Medical Centre

4:25 pm – 4:50 pm	ERCC1-XPF Dependent DNA repair: At the Cancer:Aging Interface
	Laura J. Niedernhofer, University of Pittsburgh School of Medicine

4:50 pm – 5:15 pm	Rad50 and XPD ATPase Machines and their Disease-Causing Mutations
	John A. Tainer, Visiting Professor, Lawrence Berkeley National Lab and Skaggs Institute for Chemical Biology

5:15 pm – 5:40 pm	Aberrant Base Excision Repair and Cancer
	Joann B. Sweasy, Yale University School of Medicine

5:40 pm – 6:05 pm	Specialized DNA Polymerases and Tumorigenesis
	Richard D. Wood, The University of Texas MD Anderson Cancer Center

	*The following talks were selected from the abstracts:*

6:05 pm – 6:20 pm	A DNA Polymerase-Delta Deletion Mutator Promotes Tumor Progression
	Lawrence A. Loeb, University of Washington

Wednesday, June 3

	Session VII: Bypassing DNA Damage
	Chair: Robert P. Fuchs

8:30 am – 8:35 am	Introduction of Keynote Address
	Leona D. Samson, Massachusetts Institute of Technology

8:35 am – 9:20 am	Keynote Address - Modifications and Roles of Y-family DNA polymerases eta and kappa
	Alan R. Lehmann, University of Sussex

9:20 am – 9:45 am	The Dynamics of Translesion Synthesis in Vertebrate Cells
	Julian E. Sale, MRC Laboratory of Molecular Biology

9:45 am – 10:10 am	Timing and Spacing of Ubiquitin-Dependent DNA Damage Bypass
	Yasukazu Daigaku, Cancer Research UK, London Research Institute Clare Hall Laboratories

10:10 am – 10:40 am	Coffee Break

10:40 am – 11:05 am	Protein Transactions During the Process of Translesion Synthesis in E. coli
	Robert P. Fuchs, CNRS Marseilles

11:05 am – 11:30 am	Factors Required for Template-Switch Mediated Damage Bypass and their Regulation
	Dana Branzei, F.I.R.C. Institute of Molecular Oncology

	*The following talks were selected from the abstracts:*

11:30 am – 11:45 am	DNA Polymerase Zeta Operates in Two-Polymerase Mechanisms that Determine Accurate or Mutagenic Outcome of Translesion DNA Synthesis In Human Cells
	Zvi Livneh, Weizmann Institute of Science

11:45 am – 12:00 pm	The FancI-FancD2 Complex is Required for Translesion DNA Synthesis During Interstrand Cross-link Repair
	Puck Knipscheer, Harvard Medical School

12:00 pm – 12:15 pm	Mechanism of the Pol III/IV Switch: Variation of the Toolbelt Model Involving a Single Hydrophobic Cleft and the Rim of the Sliding Clamp
	Justin M. Heltzel, University at Buffalo SUNY

12:15 pm – 12:30 pm	Regulation of the DNA Damage Response by the E. coli DNA Polymerase Manager Protein UmuD
	Penny J. Beuning, Northeastern University

	Session VIII: Implications for the Whole Organism Chair: Bevin P. Engelward

4:00 pm – 4:25 pm	Complex Responses to DNA Damaging Agents
	Leona D. Samson, Massachusetts Institute of Technology

4:25 pm – 4:50 pm	Genetic and Epigenetic Mechanisms of Exposure-Induced Recombination
	Bevin P. Engelward, Massachusetts Institute of Technology

4:50 pm – 5:15 pm	A Robust DNA Repair System in D. radiodurans
	Miroslav Radman, Faculté de Médecine – Necker, Université Paris

	*The following talks were selected from the abstracts:*

5:15 pm – 5:30 pm	Directed Evolution of Extreme Radioresistance in E. coli MG1655
	John R. Battista, Louisiana State University

5:30 pm – 5:45 pm	Characterization of ITPase Knockout Mouse
	Kunihiko Sakumi, Kyushu University

	Special Talk:
5:45 pm	Sydney Brenner --- Founding Father of Molecular Biology --- and Enfant Terrible
	Errol C. Friedberg, UT Southwestern Medical Center

Thursday, June 4

	Session IX: Repairing DNA Breaks
	Chair: Susan P. Lees-Miller

8:30 am – 8:55 am	Single-Strand Break Repair and Human Genetic Disease
	Keith W. Caldecott, University of Sussex

8:55 am – 9:20 pm	Structural Biology of DNA End Joining
	Tom Ellenberger, Washington University School of Medicine

9:20 am – 9:45 am	Mechanisms of Double-Strand Break Repair in Mycobacteria
	Stewart Shuman, Sloan-Kettering Institute

9:45 am – 10:10 am	Structural and Functional Insights into the Role of DNA-PK in NHEJ Susan P. Lees-Miller, University of Calgary

10:10 am – 10:40 am	Coffee Break

10:40 am – 11:05 am	Mre11/Rad50 Complexes and DNA Double-Strand Break Processing
	Tanya T. Paull, University of Texas at Austin

11:05 am – 11:30 am	Novel Mechanisms and Proteins in DNA Strand Break Repair in Human Cells
	Akira Yasui, Tohoku University

11:30 am – 11:55 am	Holliday Junction Resolution Mediated by the Human GEN1 Protein
	Stephen C. West, Cancer Research UK, London Research Institute Clare Hall Laboratories

	*The following talks were selected from the abstracts:*

11:55 am – 12:10 pm	`Phosphorylation Of FANCG At Serine 7 Acts As A Molecular Switch For Homologous Recombination Repair (HRR) In The Fanconi-BRCA Tumour Suppressor Pathway
	Nigel J. Jones, University of Liverpool

12:10 pm – 12:25 pm	Nuclear Proteins Involved in Mitochondrial Double-Strand Break Repair
	Lidza Kalifa, University of Rochester

	Session X: Replication Fidelity
	Chair: Thomas A. Kunkel

4:00 pm – 4:25 pm	Efficiency of Repairing Replication Errors Made by Yeast DNA Polymerase Delta
	Thomas A. Kunkel, National Institute of Environmental Health Sciences, NIH

4:25 pm – 4:50 pm	DNA Damage Recognition
	Wei Yang, National Institute of Diabetes and Digestive and Kidney Diseases, NIH

4:50 pm – 5:15 pm	Control and Function of Translesion DNA Polymerases
	Graham C. Walker, Massachusetts Institute of Technology

5:15 pm – 5:40 pm	Studies on the Mechanism of Eukaryotic Mismatch Repair and Possible Insights into the Nature of the Exo1-Independent Reaction
	Paul Modrich, Duke University Medical Center

	*The following talks were selected from the abstracts:*

5: 40 pm – 5:55 pm	MutS Recognition of DNA
	Titia K. Sixma, Netherlands Cancer Institute

5: 55 pm – 6:10 pm	Mechanism of Mismatch Repair
	Marina Elez, INSERM

6:10 pm – 6:25 pm	DNA Loop Formation By The Muts Mutl Protein Complex During Early Steps of DNA Mismatch Repair
	Joyce H. Lebbink, Erasmus Medical Center

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