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Full Scientific Program

 

Sunday, May 31

 

 

Session I: It All Starts with DNA Repair

Chair: Priscilla K. Cooper

 

8:30 am – 8:40 am

Welcome

 

Graham C. Walker, Massachusetts Institute of Technology

 

 

8:40 am – 8:45 am

Introduction of Keynote Address

 

Priscilla K. Cooper, Lawrence Berkeley National Laboratory

 

 

8:45 am – 9:30 am

Keynote Address - Meandering through the Maze of Oxidative

DNA Damage

 

Susan S. Wallace, University of Vermont

 

 

9:30 am – 9:55 am

Mechanisms of Genomic Instability During Base Excision Repair

 

            Samuel H. Wilson, , National Institute of Environmental Health Sciences. NIH

 

 

9:55 am – 10:20 am

Subpathways for Oxidative Damage Repair in the Mitochondrial

Genome

 

Sankar Mitra, University of Texas Medical Branch

 

 

10:20 am – 10:50 am

Coffee Break

 

 

 

The following talks were selected from the abstracts:

 

 

10:50 am – 11:05 am

Structural Illumination of a MutY Glycosylase Reaction Coordinate

Intermediate

 

Sheila S. David, University of California

 

 

11:05 am – 11:20 am

Structure and DNA Binding of Alkylation Response Protein AidB

 

Brandt F. Eichman, Vanderbilt University

 

 

11:20 am – 11:35 am

Thymine DNA Glycosylase is Required for Embryonic Development

and DNA Demethylation in Mammals

 

Alfonso Bellacosa, Fox Chase Cancer Center

 

 

11:35 am – 11:50 am

Arabidopsis ROS1 is a Non-Processive 5-methylcytosine DNA

Glycosylase that Initiates Demethylation through an AP

Endonuclease-Independent Excision Pathway

 

Teresa Roldan-Arjona, University of Cordoba

 

 

11:50 am – 12:05 pm

The Role of MutS and MutL in Very Short Patch Repair in

Escherichia coli.

 

Claire G. Cupples, University of Victoria

 

 

12:05 pm – 12:20 pm

Functional Redundancy and Uniqueness Among the Human RecQ

Helicases

 

Raymond Monnat, University of Washington

 

 

 

Session II: Locating Lesions and Coordinating Repair

 

Chair: Leon H. Mullenders

 

 

4:00 pm – 4:25 pm

Intersecting DNA Repair Pathways and Coordination with

Transcription and Replication

 

Priscilla K. Cooper, Lawrence Berkeley National Laboratory

 

 

4:25 pm  - 4:50 pm

DNA Damage, Transcription Stalling and Cellular Responses

 

Leon H. Mullenders, Leiden University Medical Center

 

 

            4:50 pm – 5:15 pm

            UV-Induced DNA Damage Response in Mammalian Cells

 

            Wim Vermeulen, Erasmus Medical Center

 

 

 

The following talks were selected from the abstracts:

 

 

5:15 pm – 5: 30 pm

Dynamic Damage Searching by Nucleotide Excision Repair

Proteins Investigated by Single-Molecule Fluorescence of Quantum

Dot Labeled Proteins

 

Ben Van Houten, University of Pittsburgh

 

 

5:30 pm – 5:45 pm

Molecular Basis of Multistep Damage Recognition in Mammalian

Nucleotide Excision Repair

 

Kaoru Sugasawa, Kobe University

 

 

5:45 pm – 6:00 pm

Structural and Functional Studies on the FeS Cluster Containing

Nucleotide Excision Repair Helicase XPD

 

Caroline Kisker, University of Wuerzburg

 

 

6:00 pm – 6:15 pm

            Coupled Repair Helicase Mfd

 

Richard T. Pomerantz, Rockefeller University

 

 

6:15 pm – 6:30 pm

Transcription-Coupled Gene Amplification in E. coli: Is Adaptive

Amplification Targeted to Specific Areas of the Genome in

Response to Stress?

 

Hallie Wimberly, Baylor College of Medicine

 

 

Monday, June 1

 

 

Session III: Cellular Responses to DNA Damage

 

Chair: Daniel Durocher

 

 

8:30 am – 8:35 am

Introduction of Keynote Address

 

Peggy Hsieh, National Institute of Diabetes and Digestive and

Kidney Diseases, NIH

 

 

8:35 am – 9:20 am

Cellular Responses to DNA Double-Strand Breaks

 

Stephen P. Jackson, The Wellcome Trust and Cancer Research

UK, The Gurdon Institute, University of Cambridge, UK

 

 

9:20 am - 9:45 am

A Systems Biology Approach to DNA Damage Signaling

 

Michael B. Yaffe, David H. Koch Institute for Integrative Cancer

Research, Massachusetts Institute of Technology

 

 

9:45 am – 10:10 am

ATM Signalling Relieves the Constraints to Double Strand Break

Repair Caused by Higher order Chromatin Structure

 

Penelope A. Jeggo, University of Sussex, UK

 

 

10:10 am - 10:40 am

Coffee Break

 

 

10:40 am – 11:05 am

            Regulatory Ubiquitylation at sites of DNA Double-Strand Breaks: From RNAi Screening 
            to Human Disease

 

Daniel Durocher, Samuel Lunenfeld Research Institute, Mount Sinai

Hospital

 

 

11:05 am – 11:30 am

DNA Damage Signaling: Mechanisms and Role in Human

Tumorigenesis and Treatment Response

 

Jiri Bartek, Danish Cancer Society

 

 

 

The following talks were selected from the abstracts:

 

 

11:30 am – 11:45 am

The ATM Protein Displays Distinct Spatial Dynamics at the Sites of

DNA damage

 

Paul S. Bradshaw, The Hospital for Sick Children

 

 

11:45 am - 12:00 pm

MicroRNA-Mediated Gene Silencing, a Novel Level of DNA

Damage Response Regulation

 

Joris Pothof, Erasmus University Medical Center

 

 

12:00 pm – 12:15 pm

A New Member of Genes, Mapo1, Involve in O6-Methylguanine

Induced Apoptosis

 

            Masumi Hidaka, Fukuoka Dental College

 

 

12:15 pm – 12:30 pm

            StressedTissue Stem-Cell Niches

 

John B. Hays, Oregon State University

 

 

 

            Session IV: Mutation and Mutagenesis

 

            Chair: Roger Woodgate

 

 

4:00 pm – 4:25 pm

Investigating the Mechansims of Spontaneous and Damage

Induced Mutagenesis in Escherichia coli

 

Roger Woodgate, Laboratory of Genomic Integrity, National

Instituteof Child Health and Human Development, NIH, USA

 

 

4:25 pm – 4:50 pm

Transcriptional Mutagenesis by 8-oxoguanine causes Ras

Activation in Mammalian Cells

 

Paul W. Doetsch, Emory University School of Medicine

 

 

4:50 pm – 5:15 pm

Balancing AID and DNA Repair During Somatic Hypermutation of

Immunoglobulin Genes

 

David G. Schatz, Yale University School of Medicine

 

 

 

            The following talks were selected from the abstracts:

 

 

5:15 pm – 5:30 pm

            Retrovirus Restriction

 

            Ashok Bhagwat, Wayne State University

 

 

5:30 pm – 5:45 pm

            Damage-Induced Localized Hypermutability

 

            Dmitry A. Gordenin, Natinal Institute of Environmental Health Sciences, NIH

 

 

5:45 pm – 6:00 pm

            Escherichia coli

 

            Patricia L. Foster, Indiana University

 

 

6:00pm – 6:15 pm

            Nuclear Reorganization of DNA Mismatch Repair Proteins in Response to DNA Damage

 

            Chris Heinen, University of Connecticut Health Center

 

Tuesday, June 2

 

 

 

 

            Session V: Unusual DNA Structures, Chromatin and DNA Repair

 

            Chair: Titia de Lange

 

 

8:30 am – 8:55 am

Unusual DNA Structures and Genetic Instability

 

Karen Vasquez, University of Texas M.D. Anderson Cancer Center,

 

 

8:55 am – 9:20 am

            Yet another Telomere Replication Problem

 

            Titia de Lange, Rockefeller University

 

 

9:20 am – 9:45

            The Role of the RSC Chromatin Remodeling Complex in DNA Double Strand Break Repair

 

            Jessica A. Downs, University of Sussex

 

 

 

            The following talks were selected from the abstracts:

 

 

9:45 am - 10:00 am

            Mechanistic Links between Tip60, ATM and Histone Methylation Codes During DNA Repair

 

            Brendan D. Price, Dana-Farber Cancer Institute

 

 

10:00 am – 10: 15 am

            A Histone Code for NHEJ Repair Mediates Chemotherapy Resistance

 

            Robert Hromas, University of New Mexico Cancer Center

 

 

10:15 am – 10:45 am

            Coffee Break

 

 

10:45 am – 11: 00 am

Genetic Dissection of The Mechanisms Underlying Telomere

Associated Diseases: Impact of The TRF2 Telomeric Protein on

Mouse Epidermal Stem Cells

 

            Gerdine J. Stout, Spanish National Cancer Research Center

 

 

11:00 am – 11:15 am

            Transcriptional Processing of Non-Canonical DNA Structures

 

            Philip C. Hanawalt, Stanford University

 

 

11:15 am – 11:30 am

            Incision-Dependent and Error-Free Repair of CAG/CTG Hairpins in Human Cells

 

            Guo-Min Li, University of Kentucky

 

 

11:30 am – 11:45 am

            Nucleosome Remodeling Catalyzed by the Human hMSH2-hMSH6

            Mismatch Recognition Complex

 

            Sarah Javaid, The Ohio State University

 

 

11:45 am – 12:00 pm

            Interactions of MutY Homolog (MYH) with Checkpoint Sensor Hus1/Rad1/Rad9 and Histone
            Deacetylase Hst4 in Fission Yeast, Schizosaccharomyces pombe

 

            A-Lien Lu-Chang, University of Maryland

 

 

12:00 pm – 12:15 pm

            Increased Reliance On DNA Repair In Malignant Gliomas With Hyperactive EGFR: A Proof 
            of Principle In Targeting Non-Oncogene Addiction

 

            Clark C. Chen, Dana Farber Cancer Institute

 

 

12:15 pm – 12:30 pm

            MRE11 Cleaves Topoisomerase 1-DNA Covalent Complexes to Promote Resistance
            to Camptothecin

 

            Elizabeth J. Sacho, University of Washington

 

 

 

            Session VI: Aging, Cancer and Human Disease

            Chair: Richard D. Wood

 

4:00 pm - 4:25 pm

            DNA Damage, Cancer, Aging and the Survival Response that Promotes Longevity

 

            Jan H.J. Hoeijmakers, Erasmus University Medical Centre

 

 

4:25 pm – 4:50 pm

            ERCC1-XPF Dependent DNA repair: At the Cancer:Aging Interface

 

            Laura J. Niedernhofer, University of Pittsburgh School of Medicine

 

 

4:50 pm – 5:15 pm

            Rad50 and XPD ATPase Machines and their Disease-Causing Mutations

 

            John A. Tainer, Visiting Professor, Lawrence Berkeley National Lab and Skaggs Institute
            for Chemical Biology

 

 

5:15 pm – 5:40 pm

            Aberrant Base Excision Repair and Cancer          

 

            Joann B. Sweasy, Yale University School of Medicine

 

 

5:40 pm – 6:05 pm

            Specialized DNA Polymerases and Tumorigenesis 

 

            Richard D. Wood, The University of Texas MD Anderson Cancer Center

 

 

 

            The following talks were selected from the abstracts:

 

 

6:05 pm – 6:20 pm

            A DNA Polymerase-Delta Deletion Mutator Promotes Tumor Progression

 

            Lawrence A. Loeb, University of Washington

 

 

            Wednesday, June 3

 

 

 

 

            Session VII: Bypassing DNA Damage

 

            Chair: Robert P. Fuchs

 

 

8:30 am – 8:35 am

            Introduction of Keynote Address

 

            Leona D. Samson, Massachusetts Institute of Technology

 

 

8:35 am – 9:20 am

            Keynote Address - Modifications and Roles of Y-family DNA polymerases eta and kappa

 

            Alan R. Lehmann, University of Sussex

 

 

9:20 am – 9:45 am

            The Dynamics of Translesion Synthesis in Vertebrate Cells

 

            Julian E. Sale, MRC Laboratory of Molecular Biology

 

 

9:45 am – 10:10 am

            Timing and Spacing of Ubiquitin-Dependent DNA Damage Bypass

 

            Yasukazu Daigaku, Cancer Research UK, London Research Institute Clare Hall
            Laboratories

 

 

10:10 am – 10:40 am

            Coffee Break

 

 

10:40 am – 11:05 am

            Protein Transactions During the Process of Translesion Synthesis in E. coli

 

            Robert P. Fuchs, CNRS Marseilles

 

 

11:05 am – 11:30 am

            Factors Required for Template-Switch Mediated Damage Bypass and their Regulation

 

            Dana Branzei, F.I.R.C. Institute of Molecular Oncology

 

 

 

            The following talks were selected from the abstracts:

 

 

11:30 am – 11:45 am

             DNA Polymerase Zeta Operates in Two-Polymerase Mechanisms that Determine Accurate
             or Mutagenic Outcome of Translesion DNA Synthesis In Human Cells

 

             Zvi Livneh, Weizmann Institute of Science

 

 

11:45 am – 12:00 pm

             The FancI-FancD2 Complex is Required for Translesion DNA Synthesis During Interstrand
             Cross-link Repair

 

             Puck Knipscheer, Harvard Medical School

 

 

12:00 pm – 12:15 pm

             Mechanism of the Pol III/IV Switch:  Variation of the Toolbelt Model Involving a Single
             Hydrophobic Cleft and the Rim of the Sliding Clamp

 

             Justin M. Heltzel, University at Buffalo SUNY

 

 

12:15 pm – 12:30 pm

             Regulation of the DNA Damage Response by the E. coli DNA Polymerase Manager Protein
             UmuD

 

             Penny J. Beuning, Northeastern University

 

 

 

             Session VIII: Implications for the Whole Organism

             Chair: Bevin P. Engelward

 

 

4:00 pm – 4:25 pm

             Complex Responses to DNA Damaging Agents

 

             Leona D. Samson, Massachusetts Institute of Technology

 

 

4:25 pm – 4:50 pm

             Genetic and Epigenetic Mechanisms of Exposure-Induced Recombination

 

             Bevin P. Engelward, Massachusetts Institute of Technology

 

 

4:50 pm – 5:15 pm

             A Robust DNA Repair System in D. radiodurans

 

             Miroslav Radman, Faculté de Médecine – Necker, Université Paris

 

 

 

             The following talks were selected from the abstracts:

 

 

5:15 pm – 5:30 pm

             Directed Evolution of Extreme Radioresistance in E. coli MG1655 

 

             John R. Battista, Louisiana State University

 

 

5:30 pm – 5:45 pm

             Characterization of ITPase Knockout Mouse

 

             Kunihiko Sakumi, Kyushu University

 

 

 

             Special Talk:

5:45 pm

             Sydney Brenner --- Founding Father of Molecular Biology --- and Enfant Terrible

 

             Errol C. Friedberg, UT Southwestern Medical Center

 

 

Thursday, June 4

 

 

 

 

             Session IX: Repairing DNA Breaks

 

             Chair: Susan P. Lees-Miller

 

 

8:30 am – 8:55 am

             Single-Strand Break Repair and Human Genetic Disease

 

             Keith W. Caldecott, University of Sussex

 

 

8:55 am – 9:20 pm

             Structural Biology of DNA End Joining

 

             Tom Ellenberger, Washington University School of Medicine

 

 

9:20 am – 9:45 am

             Mechanisms of Double-Strand Break Repair in Mycobacteria

 

             Stewart Shuman, Sloan-Kettering Institute

 

 

9:45 am – 10:10 am

             Structural and Functional Insights into the Role of DNA-PK in NHEJ

             Susan P. Lees-Miller, University of Calgary           

 

 

10:10 am – 10:40 am

             Coffee Break

 

 

10:40 am – 11:05 am

             Mre11/Rad50 Complexes and DNA Double-Strand Break Processing

 

             Tanya T. Paull, University of Texas at Austin

 

 

11:05 am – 11:30 am

             Novel Mechanisms and Proteins in DNA Strand Break Repair in Human Cells

 

             Akira Yasui, Tohoku University

 

 

11:30 am – 11:55 am

             Holliday Junction Resolution Mediated by the Human GEN1 Protein

 

             Stephen C. West, Cancer Research UK, London Research Institute Clare Hall Laboratories

 

 

 

             The following talks were selected from the abstracts:

 

 

11:55 am – 12:10 pm

             `Phosphorylation Of FANCG At Serine 7 Acts As A Molecular Switch For Homologous
              Recombination Repair (HRR) In The Fanconi-BRCA Tumour Suppressor Pathway

 

              Nigel J. Jones, University of Liverpool

 

 

12:10 pm – 12:25 pm

              Nuclear Proteins Involved in Mitochondrial Double-Strand Break Repair

 

              Lidza Kalifa, University of Rochester

 

 

 

              Session X: Replication Fidelity

 

              Chair: Thomas A. Kunkel

 

 

4:00 pm – 4:25 pm

              Efficiency of Repairing Replication Errors Made by Yeast DNA Polymerase Delta

 

              Thomas A. Kunkel, National Institute of Environmental Health Sciences, NIH

 

 

4:25 pm – 4:50 pm

              DNA Damage Recognition

 

              Wei Yang, National Institute of Diabetes and Digestive and Kidney Diseases, NIH

 

 

4:50 pm – 5:15 pm

              Control and Function of Translesion DNA Polymerases

 

              Graham C. Walker, Massachusetts Institute of Technology

 

 

5:15 pm – 5:40 pm

              Studies on the Mechanism of Eukaryotic Mismatch Repair and Possible Insights into the
              Nature of the Exo1-Independent Reaction

 

              Paul Modrich, Duke University Medical Center

 

 

 

              The following talks were selected from the abstracts:

 

 

5: 40 pm – 5:55 pm

              MutS Recognition of DNA

 

              Titia K. Sixma, Netherlands Cancer Institute

 

 

5: 55 pm – 6:10 pm

              Mechanism of Mismatch Repair

 

              Marina Elez, INSERM

 

 

6:10 pm – 6:25 pm

              DNA Loop Formation By The Muts Mutl Protein Complex During Early Steps of DNA
              Mismatch Repair

 

              Joyce H. Lebbink, Erasmus Medical Center

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