Full Scientific Program


Sunday, May 31



Session I: It All Starts with DNA Repair

Chair: Priscilla K. Cooper


8:30 am – 8:40 am



Graham C. Walker, Massachusetts Institute of Technology



8:40 am – 8:45 am

Introduction of Keynote Address


Priscilla K. Cooper, Lawrence Berkeley National Laboratory



8:45 am – 9:30 am

Keynote Address - Meandering through the Maze of Oxidative

DNA Damage


Susan S. Wallace, University of Vermont



9:30 am – 9:55 am

Mechanisms of Genomic Instability During Base Excision Repair


            Samuel H. Wilson, , National Institute of Environmental Health Sciences. NIH



9:55 am – 10:20 am

Subpathways for Oxidative Damage Repair in the Mitochondrial



Sankar Mitra, University of Texas Medical Branch



10:20 am – 10:50 am

Coffee Break




The following talks were selected from the abstracts:



10:50 am – 11:05 am

Structural Illumination of a MutY Glycosylase Reaction Coordinate



Sheila S. David, University of California



11:05 am – 11:20 am

Structure and DNA Binding of Alkylation Response Protein AidB


Brandt F. Eichman, Vanderbilt University



11:20 am – 11:35 am

Thymine DNA Glycosylase is Required for Embryonic Development

and DNA Demethylation in Mammals


Alfonso Bellacosa, Fox Chase Cancer Center



11:35 am – 11:50 am

Arabidopsis ROS1 is a Non-Processive 5-methylcytosine DNA

Glycosylase that Initiates Demethylation through an AP

Endonuclease-Independent Excision Pathway


Teresa Roldan-Arjona, University of Cordoba



11:50 am – 12:05 pm

The Role of MutS and MutL in Very Short Patch Repair in

Escherichia coli.


Claire G. Cupples, University of Victoria



12:05 pm – 12:20 pm

Functional Redundancy and Uniqueness Among the Human RecQ



Raymond Monnat, University of Washington




Session II: Locating Lesions and Coordinating Repair


Chair: Leon H. Mullenders



4:00 pm – 4:25 pm

Intersecting DNA Repair Pathways and Coordination with

Transcription and Replication


Priscilla K. Cooper, Lawrence Berkeley National Laboratory



4:25 pm  - 4:50 pm

DNA Damage, Transcription Stalling and Cellular Responses


Leon H. Mullenders, Leiden University Medical Center



            4:50 pm – 5:15 pm

            UV-Induced DNA Damage Response in Mammalian Cells


            Wim Vermeulen, Erasmus Medical Center




The following talks were selected from the abstracts:



5:15 pm – 5: 30 pm

Dynamic Damage Searching by Nucleotide Excision Repair

Proteins Investigated by Single-Molecule Fluorescence of Quantum

Dot Labeled Proteins


Ben Van Houten, University of Pittsburgh



5:30 pm – 5:45 pm

Molecular Basis of Multistep Damage Recognition in Mammalian

Nucleotide Excision Repair


Kaoru Sugasawa, Kobe University



5:45 pm – 6:00 pm

Structural and Functional Studies on the FeS Cluster Containing

Nucleotide Excision Repair Helicase XPD


Caroline Kisker, University of Wuerzburg



6:00 pm – 6:15 pm

            Coupled Repair Helicase Mfd


Richard T. Pomerantz, Rockefeller University



6:15 pm – 6:30 pm

Transcription-Coupled Gene Amplification in E. coli: Is Adaptive

Amplification Targeted to Specific Areas of the Genome in

Response to Stress?


Hallie Wimberly, Baylor College of Medicine



Monday, June 1



Session III: Cellular Responses to DNA Damage


Chair: Daniel Durocher



8:30 am – 8:35 am

Introduction of Keynote Address


Peggy Hsieh, National Institute of Diabetes and Digestive and

Kidney Diseases, NIH



8:35 am – 9:20 am

Cellular Responses to DNA Double-Strand Breaks


Stephen P. Jackson, The Wellcome Trust and Cancer Research

UK, The Gurdon Institute, University of Cambridge, UK



9:20 am - 9:45 am

A Systems Biology Approach to DNA Damage Signaling


Michael B. Yaffe, David H. Koch Institute for Integrative Cancer

Research, Massachusetts Institute of Technology



9:45 am – 10:10 am

ATM Signalling Relieves the Constraints to Double Strand Break

Repair Caused by Higher order Chromatin Structure


Penelope A. Jeggo, University of Sussex, UK



10:10 am - 10:40 am

Coffee Break



10:40 am – 11:05 am

            Regulatory Ubiquitylation at sites of DNA Double-Strand Breaks: From RNAi Screening 
            to Human Disease


Daniel Durocher, Samuel Lunenfeld Research Institute, Mount Sinai




11:05 am – 11:30 am

DNA Damage Signaling: Mechanisms and Role in Human

Tumorigenesis and Treatment Response


Jiri Bartek, Danish Cancer Society




The following talks were selected from the abstracts:



11:30 am – 11:45 am

The ATM Protein Displays Distinct Spatial Dynamics at the Sites of

DNA damage


Paul S. Bradshaw, The Hospital for Sick Children



11:45 am - 12:00 pm

MicroRNA-Mediated Gene Silencing, a Novel Level of DNA

Damage Response Regulation


Joris Pothof, Erasmus University Medical Center



12:00 pm – 12:15 pm

A New Member of Genes, Mapo1, Involve in O6-Methylguanine

Induced Apoptosis


            Masumi Hidaka, Fukuoka Dental College



12:15 pm – 12:30 pm

            StressedTissue Stem-Cell Niches


John B. Hays, Oregon State University




            Session IV: Mutation and Mutagenesis


            Chair: Roger Woodgate



4:00 pm – 4:25 pm

Investigating the Mechansims of Spontaneous and Damage

Induced Mutagenesis in Escherichia coli


Roger Woodgate, Laboratory of Genomic Integrity, National

Instituteof Child Health and Human Development, NIH, USA



4:25 pm – 4:50 pm

Transcriptional Mutagenesis by 8-oxoguanine causes Ras

Activation in Mammalian Cells


Paul W. Doetsch, Emory University School of Medicine



4:50 pm – 5:15 pm

Balancing AID and DNA Repair During Somatic Hypermutation of

Immunoglobulin Genes


David G. Schatz, Yale University School of Medicine




            The following talks were selected from the abstracts:



5:15 pm – 5:30 pm

            Retrovirus Restriction


            Ashok Bhagwat, Wayne State University



5:30 pm – 5:45 pm

            Damage-Induced Localized Hypermutability


            Dmitry A. Gordenin, Natinal Institute of Environmental Health Sciences, NIH



5:45 pm – 6:00 pm

            Escherichia coli


            Patricia L. Foster, Indiana University



6:00pm – 6:15 pm

            Nuclear Reorganization of DNA Mismatch Repair Proteins in Response to DNA Damage


            Chris Heinen, University of Connecticut Health Center


Tuesday, June 2





            Session V: Unusual DNA Structures, Chromatin and DNA Repair


            Chair: Titia de Lange



8:30 am – 8:55 am

Unusual DNA Structures and Genetic Instability


Karen Vasquez, University of Texas M.D. Anderson Cancer Center,



8:55 am – 9:20 am

            Yet another Telomere Replication Problem


            Titia de Lange, Rockefeller University



9:20 am – 9:45

            The Role of the RSC Chromatin Remodeling Complex in DNA Double Strand Break Repair


            Jessica A. Downs, University of Sussex




            The following talks were selected from the abstracts:



9:45 am - 10:00 am

            Mechanistic Links between Tip60, ATM and Histone Methylation Codes During DNA Repair


            Brendan D. Price, Dana-Farber Cancer Institute



10:00 am – 10: 15 am

            A Histone Code for NHEJ Repair Mediates Chemotherapy Resistance


            Robert Hromas, University of New Mexico Cancer Center



10:15 am – 10:45 am

            Coffee Break



10:45 am – 11: 00 am

Genetic Dissection of The Mechanisms Underlying Telomere

Associated Diseases: Impact of The TRF2 Telomeric Protein on

Mouse Epidermal Stem Cells


            Gerdine J. Stout, Spanish National Cancer Research Center



11:00 am – 11:15 am

            Transcriptional Processing of Non-Canonical DNA Structures


            Philip C. Hanawalt, Stanford University



11:15 am – 11:30 am

            Incision-Dependent and Error-Free Repair of CAG/CTG Hairpins in Human Cells


            Guo-Min Li, University of Kentucky



11:30 am – 11:45 am

            Nucleosome Remodeling Catalyzed by the Human hMSH2-hMSH6

            Mismatch Recognition Complex


            Sarah Javaid, The Ohio State University



11:45 am – 12:00 pm

            Interactions of MutY Homolog (MYH) with Checkpoint Sensor Hus1/Rad1/Rad9 and Histone
            Deacetylase Hst4 in Fission Yeast, Schizosaccharomyces pombe


            A-Lien Lu-Chang, University of Maryland



12:00 pm – 12:15 pm

            Increased Reliance On DNA Repair In Malignant Gliomas With Hyperactive EGFR: A Proof 
            of Principle In Targeting Non-Oncogene Addiction


            Clark C. Chen, Dana Farber Cancer Institute



12:15 pm – 12:30 pm

            MRE11 Cleaves Topoisomerase 1-DNA Covalent Complexes to Promote Resistance
            to Camptothecin


            Elizabeth J. Sacho, University of Washington




            Session VI: Aging, Cancer and Human Disease

            Chair: Richard D. Wood


4:00 pm - 4:25 pm

            DNA Damage, Cancer, Aging and the Survival Response that Promotes Longevity


            Jan H.J. Hoeijmakers, Erasmus University Medical Centre



4:25 pm – 4:50 pm

            ERCC1-XPF Dependent DNA repair: At the Cancer:Aging Interface


            Laura J. Niedernhofer, University of Pittsburgh School of Medicine



4:50 pm – 5:15 pm

            Rad50 and XPD ATPase Machines and their Disease-Causing Mutations


            John A. Tainer, Visiting Professor, Lawrence Berkeley National Lab and Skaggs Institute
            for Chemical Biology



5:15 pm – 5:40 pm

            Aberrant Base Excision Repair and Cancer          


            Joann B. Sweasy, Yale University School of Medicine



5:40 pm – 6:05 pm

            Specialized DNA Polymerases and Tumorigenesis 


            Richard D. Wood, The University of Texas MD Anderson Cancer Center




            The following talks were selected from the abstracts:



6:05 pm – 6:20 pm

            A DNA Polymerase-Delta Deletion Mutator Promotes Tumor Progression


            Lawrence A. Loeb, University of Washington



            Wednesday, June 3





            Session VII: Bypassing DNA Damage


            Chair: Robert P. Fuchs



8:30 am – 8:35 am

            Introduction of Keynote Address


            Leona D. Samson, Massachusetts Institute of Technology



8:35 am – 9:20 am

            Keynote Address - Modifications and Roles of Y-family DNA polymerases eta and kappa


            Alan R. Lehmann, University of Sussex



9:20 am – 9:45 am

            The Dynamics of Translesion Synthesis in Vertebrate Cells


            Julian E. Sale, MRC Laboratory of Molecular Biology



9:45 am – 10:10 am

            Timing and Spacing of Ubiquitin-Dependent DNA Damage Bypass


            Yasukazu Daigaku, Cancer Research UK, London Research Institute Clare Hall



10:10 am – 10:40 am

            Coffee Break



10:40 am – 11:05 am

            Protein Transactions During the Process of Translesion Synthesis in E. coli


            Robert P. Fuchs, CNRS Marseilles



11:05 am – 11:30 am

            Factors Required for Template-Switch Mediated Damage Bypass and their Regulation


            Dana Branzei, F.I.R.C. Institute of Molecular Oncology




            The following talks were selected from the abstracts:



11:30 am – 11:45 am

             DNA Polymerase Zeta Operates in Two-Polymerase Mechanisms that Determine Accurate
             or Mutagenic Outcome of Translesion DNA Synthesis In Human Cells


             Zvi Livneh, Weizmann Institute of Science



11:45 am – 12:00 pm

             The FancI-FancD2 Complex is Required for Translesion DNA Synthesis During Interstrand
             Cross-link Repair


             Puck Knipscheer, Harvard Medical School



12:00 pm – 12:15 pm

             Mechanism of the Pol III/IV Switch:  Variation of the Toolbelt Model Involving a Single
             Hydrophobic Cleft and the Rim of the Sliding Clamp


             Justin M. Heltzel, University at Buffalo SUNY



12:15 pm – 12:30 pm

             Regulation of the DNA Damage Response by the E. coli DNA Polymerase Manager Protein


             Penny J. Beuning, Northeastern University




             Session VIII: Implications for the Whole Organism

             Chair: Bevin P. Engelward



4:00 pm – 4:25 pm

             Complex Responses to DNA Damaging Agents


             Leona D. Samson, Massachusetts Institute of Technology



4:25 pm – 4:50 pm

             Genetic and Epigenetic Mechanisms of Exposure-Induced Recombination


             Bevin P. Engelward, Massachusetts Institute of Technology



4:50 pm – 5:15 pm

             A Robust DNA Repair System in D. radiodurans


             Miroslav Radman, Faculté de Médecine – Necker, Université Paris




             The following talks were selected from the abstracts:



5:15 pm – 5:30 pm

             Directed Evolution of Extreme Radioresistance in E. coli MG1655 


             John R. Battista, Louisiana State University



5:30 pm – 5:45 pm

             Characterization of ITPase Knockout Mouse


             Kunihiko Sakumi, Kyushu University




             Special Talk:

5:45 pm

             Sydney Brenner --- Founding Father of Molecular Biology --- and Enfant Terrible


             Errol C. Friedberg, UT Southwestern Medical Center



Thursday, June 4





             Session IX: Repairing DNA Breaks


             Chair: Susan P. Lees-Miller



8:30 am – 8:55 am

             Single-Strand Break Repair and Human Genetic Disease


             Keith W. Caldecott, University of Sussex



8:55 am – 9:20 pm

             Structural Biology of DNA End Joining


             Tom Ellenberger, Washington University School of Medicine



9:20 am – 9:45 am

             Mechanisms of Double-Strand Break Repair in Mycobacteria


             Stewart Shuman, Sloan-Kettering Institute



9:45 am – 10:10 am

             Structural and Functional Insights into the Role of DNA-PK in NHEJ

             Susan P. Lees-Miller, University of Calgary           



10:10 am – 10:40 am

             Coffee Break



10:40 am – 11:05 am

             Mre11/Rad50 Complexes and DNA Double-Strand Break Processing


             Tanya T. Paull, University of Texas at Austin



11:05 am – 11:30 am

             Novel Mechanisms and Proteins in DNA Strand Break Repair in Human Cells


             Akira Yasui, Tohoku University



11:30 am – 11:55 am

             Holliday Junction Resolution Mediated by the Human GEN1 Protein


             Stephen C. West, Cancer Research UK, London Research Institute Clare Hall Laboratories




             The following talks were selected from the abstracts:



11:55 am – 12:10 pm

             `Phosphorylation Of FANCG At Serine 7 Acts As A Molecular Switch For Homologous
              Recombination Repair (HRR) In The Fanconi-BRCA Tumour Suppressor Pathway


              Nigel J. Jones, University of Liverpool



12:10 pm – 12:25 pm

              Nuclear Proteins Involved in Mitochondrial Double-Strand Break Repair


              Lidza Kalifa, University of Rochester




              Session X: Replication Fidelity


              Chair: Thomas A. Kunkel



4:00 pm – 4:25 pm

              Efficiency of Repairing Replication Errors Made by Yeast DNA Polymerase Delta


              Thomas A. Kunkel, National Institute of Environmental Health Sciences, NIH



4:25 pm – 4:50 pm

              DNA Damage Recognition


              Wei Yang, National Institute of Diabetes and Digestive and Kidney Diseases, NIH



4:50 pm – 5:15 pm

              Control and Function of Translesion DNA Polymerases


              Graham C. Walker, Massachusetts Institute of Technology



5:15 pm – 5:40 pm

              Studies on the Mechanism of Eukaryotic Mismatch Repair and Possible Insights into the
              Nature of the Exo1-Independent Reaction


              Paul Modrich, Duke University Medical Center




              The following talks were selected from the abstracts:



5: 40 pm – 5:55 pm

              MutS Recognition of DNA


              Titia K. Sixma, Netherlands Cancer Institute



5: 55 pm – 6:10 pm

              Mechanism of Mismatch Repair


              Marina Elez, INSERM



6:10 pm – 6:25 pm

              DNA Loop Formation By The Muts Mutl Protein Complex During Early Steps of DNA
              Mismatch Repair


              Joyce H. Lebbink, Erasmus Medical Center