6th ASM Conference on
Candida and Candidiasis 
January 13-17, 2002
Tampa, Florida

Contents of This Page:

Scientific Organizers
Advisory Committee
Scientific Program

Links to Other Pages:

General Information
Registration Form

Scientific Organizers

W. LaJean Chaffin
Texas Tech University Health Sciences Center

William G. Merz
Johns Hopkins University

Advisory Committee

Scott Filler, Harbor UCLA Medical Center
Mahmoud Ghannoum, Case Western Reserve University
Joy Sturtevant, Georgetown University
Ted White, Seattle Biomedical Research Institute
 

Scientific Program

The program is subject to change.
_____________________________________________

Sunday, January 13, 2002

1 - 5 pm: Afternoon Registration

7:30 pm: Opening Remarks

7:40 - 9 pm: Opening Session/Group Discussion: What Defines Virulence in Candida Species and How Do You Evaluate It?
Chair: Frank Odds, University of Aberdeen

Panel Discussion
Bernard Hube, Robert Koch Institute
Richard Calderone, Georgetown University
Cιsar Nombela, Universidad de Complutense

9 - 11 pm: Welcome Reception

_____________________________________________

Monday, January 14, 2002

8:30 – 10 am: Session I: Genetics and Genomics
Chair: Paul Magee, University of Minnesota

8:30 – 8:50 am: In Vitro And In Vivo Studies On Sex In
Candida albicans
Paul Magee, University of Minnesota

8:50 – 9:10 am: MDS3: A pH-Response and Virulence Gene Identified by Insertional Mutagenesis
Vincent Bruno, Columbia University

9:10 – 9:30 am: Genetic Analysis of Filamentous Growth in C. albicans by Transposon Mutagensis 
Alexander Johnson, University of California at San Francisco

9:30 – 9:50 am: Microarray Analysis of Macrophage-Candida Interactions
Mike Lorenz, Whitehead Institute for Biomedical Research

10 – 10:30 am: Coffee Break

10:30 am – 12 pm: Session II: Epidemiology and Population Studies
Chair: Rana Hajjeh, Centers for Disease Control and Prevention

10:30 – 10:50 am: The Changing Epidemiology of Candidemia
Rana Hajjeh, Centers for Disease Control and Prevention

10:50 – 11:10 am: Differentiation and Gene Flow Among Populations of Candida albicans from the Old and New Worlds
Jianping Xu, McMaster University

11:10 – 11:30 am: Sentinel Surveillance of Candidemia: Trends in Species Distribution and Antifungal Susceptibility
Michael Pfaller, University of Iowa College of Medicine

11:30 – 11:50 am: Genomic Markers of Pathogenicity of Candida albicans
Ningxin Zhang, Institute of Molecular Biosciences, Massey University

12 – 1:30 pm: Lunch

1:30 – 3 pm: Session III: Cell Wall and Surface Molecules 
Chair: Paula Sundstrom, Ohio State University

1:30 – 1:50 pm: Role of Transglutaminase-Mediated Covalent Cross-Linking Between Host Cells and Candida albicans in Oroesophageal Candidiasis
Paula Sundstrom, Ohio State University                       

1:50 – 2:10 pm: Deceptive Correlation of Phenotypes with Genotype at the HWP1 Locus
William Fonzi, Georgetown University

2:10 – 2:30 pm: ALS1 Required for Early Blastospore to
Hyphal Transition
Yue Fu, Harbor UCLA Research and Education Institute

2:30 – 2:50 pm: Cell Wall Glycosylation Candida albicans and Its Importance to Host Interactions
Neil Gow, University of Aberdeen

3 – 3:30 pm: Coffee Break

3:30 – 5 pm: Poster Presentations I

7:30 – 9 pm: Workshop on Genome Annotation
Facilitator:  Aaron Mitchell, Columbia University

Investigators who are involved in annotation are invited to participate, give updates on their progress, availability, and to discuss techniques and nomenclature for a consensus. Other meeting attendees with an interest in the results are invited to attend.

_____________________________________________

Tuesday, January 15, 2002

8:30 – 10 am: Session VI: New Candida Scientists: Molecular Genetics, Signaling and Morphogenesis
Chair: Joy Sturtevant, Georgetown University

8:30 – 8:45 am: Identification of Centromere Binding Proteins of the Human Pathogenic Yeast Candida glabrata
T. Stoyan University of California, Santa Barbara

8:45 – 9 am: Progressive Carboxy-Terminal Truncation of Candida albicans-RIM101
D. Zeller, Universitaet Wuerzburg, Wuerzburg, Germany

9 – 9:15 am: Identification of Downstream Effectors of EFG1 and CPH1, two Transcription Factors Essential for Virulence
K. Sohn, Fraunhofer IGB, Stuttgart, Germany

9:15 – 9:30 am: Characterization of Morphological Mutants of Candida albicans Altered in Farnesol-Mediated Quorum Sensing
J. M. Hornby, University of Nebraska-Lincoln

9:30 – 9:45 am: Deficiencies in the Essential GPI Biosynthetic Proteins Gpi1p and Gpi3p Lead to Cell Wall Defects in Candida albicans
E. E. Robinson, University of Illinois, Urbana

9:45 – 10 am: Genome-Wide Expression Profiling of Phenotypic Switching in Candida albicans
C. Lan, University of California, San Francisco

10 – 10:30 am: Coffee Break

10:30 am – 12 pm: Session V: Host Response
Chair: Scott Filler, Harbor UCLA Medical Center

10:30 – 10:50 am: Immune Response to Hematogenously Disseminated Candidiasis in Mice
Scott Filler, Harbor UCLA Medical Center

10:50 – 11:10 am: Pathogenesis of Oropharyngeal Candidiasis in Transgenic Mice Expressing HIV-1
Louis de Repentigny, Hospital Sainte Justine

11:10 – 11:30 am: Distinct Mucosal Anti-Candida Host Defenses at the Oral and Vaginal Mucosa: Implications for Susceptibility to Infection
Paul Fidel, Louisiana State University Health Sciences Center

11:30 –11:50 am: Receptors and Effectors in the Recognition of Candida albicans by the Innate Immune System: Implication for Virulence and Immunity
Luigina Romani, University of Perugia Medical School

12:00 – 1:30 pm: Lunch

1:30 – 3 pm: Session VI: Signaling and Morphogenesis
Chair: Alistair Brown, University of Aberdeen

1:30 – 1:50 pm: Gene Regulation By Morphogenetic
Signaling Pathways
Alistair Brown, University of Aberdeen

1:50 – 2:10 pm: Role of Protein Kinase A-Isoforms in Morphogenesis of Candida albicans
Joachim Ernst, Universitaet Duesseldorf

2:10 – 2:30 pm: The Regulation of Switching and Phase-Regulated Gene Expression in Candida albicans and Candida glabrata.
David Soll, University of Iowa

2:30 – 2:45 pm: Coffee Break

2:45 – 3:30 pm: Session VI continued

2:45 – 3:05 pm: From Transcriptional Regulation to Hyphal Morphogenesis
Haoping Liu, University of California, Irvine

3:05 – 3:25 pm: Role of the Cell Cycle and Cytoskeleton in Candida albicans Morphogenesis
Judith Berman, University of Minnesota

3:30 – 5 pm: Poster Presentations II

_____________________________________________

Wednesday, January 16, 2002

8:30 – 10 am: Session VII: New Candida Scientists: Infection, Host Response and Cell Wall
Chair: Fritz Muehlschlegel, Kent, United Kingdom

8:30 – 8:45 am: Transcription Profiling of Candida albicans Genes Expressed in Human Blood
C. Fradin, Robert Koch Institut, Germany

8:45 – 9 am: Alterations in Cell Wall Glucans and Mannan in a Candida albicans Strain Deleted of a Histidine Kinase [CHK1] Gene
M. D. Kruppa, Georgetown University Medical Center

9 – 9:15 am: Site Directed Mutational Analysis of Cdr1p, an ABC Multidrug Transporter of Candida albicans
S. Shukla, Jawaharlal Nehru University, India

9:15 – 9:30 am: Involvement of Drosophila melanogaster Toll Signaling Pathway in Resistance to Candida albicans Infection: Development of a New Host-Pathogen Interaction Model System
A. Alarco, Biotechnology Research Institute, National Research Council, Canada

9:30 – 9:45 am: Transcriptional Response of Human and Murine Macrophages to Infection with Saccharomyces cerevisiae and Candida albicans
M. Kelly, University College Dublin, Ireland

9:45 – 10 am: Immunogenicity of Rbf1p in Patients with Oropharyngeal Candidiasis and Disseminated Candidiasis
M. Checkley, University of Florida

10 – 10:30 am: Coffee Break

10:30 am – 12 pm: Session VIII: Diagnosis and Treatment
Chair: James Cutler, Montana State University

10:30 – 10:50 am: Antibody Specificity and Protective Potential Against Experimental Candidiasis
James Cutler, Montana State University

10:50 – 11:10 am: The New Triazoles for Treating Candidiasis
Tom Walsh, National Institute of Health, NCI

11:10 – 11:30 am: Antibody and Antigen Detection Tests, Past, Present … and Future
Daniel Poulain, INSERM

11:30 – 11:50 am: Do Immunomodulators Have a Role in Treating Candida?
David Stevens, Santa Clara Valley Medical Center

12 – 1:30 pm: Lunch

1:30 – 3 pm: Session IX: Non-albicans Virulence  
Chair: Brendan Cormack, Johns Hopkins Medical School

1:30 – 1:50 pm: Genetics of Virulence in the Pathogenic Yeast, Candida glabrata
Brendan Cormack, Johns Hopkins Medical School

1:50 – 2:10 pm: Candida dubliniensis Virulence
David Coleman, Trinity College, University of Dublin

2:10 – 2:30 pm: Function of the Prosequence in the Maturation and Secretion of Candida Secreted Aspartic Proteases
Michel Monod, University Hopsital Lausanne

2:30 – 2:50 pm: Isolation and Characterisation of a Putative Hypervirulent Candida glabrata Mutant
Ken Haynes, Imperial College

3 – 3:30 pm: Coffee Break

3:30 – 5 pm: Poster Presentations III

7 – 10 pm: Evening Reception and Banquet

_____________________________________________

Thursday, January 17, 2002

8:30 – 9:30 am: Session X: Biofilms
Chair: Mahmoud Ghannoum, Case Western Reserve University

  8:30 – 8:50 am: C. albicans Biofilms: Formation, Architecture and Gene Expression
Mahmoud Ghannoum, Case Western Reserve University

8:50 – 9:10 am: Candida Biofilms and Drug Resistance
Julia Douglas, University of Glasgow

9:10 – 9:30 am: Multidrug Efflux Pumps: Expression Patterns and Contribution to Sessile Recalcitrance in Candida albicans Biofilms
Jose Lopez-Ribot, University of Texas Health Science Center at San Antonio

9:30 – 10 am: Coffee Break

10 am – 12 pm: Session XI: Drug Resistance
Chair: Ted White, Seattle Biomedical Research Institute

10 – 10:20 am: Stages of Azole Susceptibility and Resistance in Candida albicans
Ted White, Seattle Biomedical Research Institute

10:20 – 10:40 am: Tolerance and Resistance to Antifungal Drugs Operate by Distinct Mechanisms
Dominique Sanglard, University Hopsital Lausanne

10:40 – 11 am: Azole Resistance and the CYP51 Sterol 14-Demethylase System
Steve Kelly, University of Wales Aberystwyth

11 – 11:20 am: The Role of the MDR1 Gene in Candida albicans Drug Resistance
Joachim Morschhauser, Universitaet Wuerzburg

11:20 – 11:40 am: New Molecular Alterations in Azole-Resistant Candida albicans Clinical Isolates Overexpressing CDR1 and CDR2
Martine Raymond, Institut de Recherches Cliniques de Montrιal

12 – 1 pm: Conference Conclusion/Lunch

Comments on meeting
Discussion of next meeting