David Brow

Brow David 250

David Brow is a professor of Biomolecular Chemistry at the University of Wisconsin School of Medicine and Public Health. His lab studies how RNA and protein cooperate to carry out two key steps of gene expression, pre-mRNA splicing and transcription termination, using the yeast Saccharomyces cerevisiae as a model. Dr. Brow is best known for his studies on the biogenesis and function of U6 RNA, which forms the catalytic core of the spliceosome, and for discovering a termination pathway for non-coding RNAs that uses the Nrd1, Nab3 and Sen1 proteins. Important recent accomplishments from Dr. Brow and coworkers include the first high-resolution map of RNA polymerase II occupancy across a eukaryotic genome and the first crystal structure of an RNA-binding protein containing 4 RNA recognition motifs bound to its RNA partner. Dr. Brow is also deeply involved in graduate and medical student education, for which he received the UW-Madison Chancellor’s Distinguished Teaching Award.


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