Edward Marcotte

Marcotte Edward 250

The Marcotte lab uses protein mass spectrometry, systems and synthetic biology, and bioinformatics to study deeply conserved gene systems that underlie genetic traits and diseases. Previously, Marcotte and colleagues reconstructed genetic “wiring diagrams” for cells (first yeast, later multicellular organisms) in order to discover genes’ functions and to link genes to traits. More recently, they developed the “phenologs” method to identify human disease genes based on finding equivalent diseases in distant species, leading to the discovery of a yeast model of angiogenesis and the finding that a common antifungal drug blocks new blood vessel growth. Most recently, the group has been systematically “humanizing” yeast in order to study human gene function and genetic variation in a simplified organism, and has found that many genes involved in basic cellular processes are exchangeable from humans to yeast.



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