James A. DeCaprio, M.D. is a Professor of Medicine at Harvard Medical School and Principal Investigator at the Dana-Farber Cancer Institute. His laboratory focuses on the discovery of fundamental biological processes that when perturbed by DNA tumor viruses contribute to cancer. His laboratory identifies cellular factors that bind specifically to viral oncoproteins and determines the biologic consequences that occur when they become mutated or perturbed by viruses. For example, his laboratory was the first to describe the mammalian DREAM (DP, RB-related, E2F, and MuvB) complex and demonstrate that it serves as the master coordinator of cell cycle dependent gene expression. His laboratory studies the family of polyomaviruses including Merkel cell polyomavirus and its contribution to the highly aggressive skin cancer Merkel cell carcinoma. Their studies indicate that the Merkel cell polyomavirus large and small T antigens are capable of hijacking cellular processes that drive tumorigenesis to the same level and in a similar manner as tens of thousands of somatic genome alterations.