James Konopka

Konopka James 120

James Konopka is a Professor of Molecular Genetics and Microbiology at Stony Brook University. Dr. Konopka’s research on the mechanisms that regulate cell signaling and morphogenesis has had important impact on diverse areas including leukemia, G protein coupled receptors, and fungal morphogenesis. Current studies are aimed at identifying the virulence mechanisms of the human fungal pathogen Candida albicans. One major area of research is to define the roles of the plasma membrane in virulence, as this essential barrier mediates many critical functions and is a target for antifungal drugs. Recent work has focused on the role of plasma membrane subdomains in promoting morphogenesis and resistance to stress. The Konopka lab is also studying the mechanisms by which the sugar N-acetylglucosamine (GlcNAc) induces hyphal morphogenesis and virulence gene expression in C. albicans. These studies are helping to reveal new roles for GlcNAc signaling in fungi and other organisms.



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