William Margolin

Margolin William 250

William Margolin, Professor of Microbiology and Molecular Genetics at the McGovern Medical School in Houston, studies how bacterial cells self-organize, with particular focus on the fundamental process of cytokinesis in Escherichia coli. One of the pioneers in visualizing protein dynamics in bacterial cells, Dr. Margolin uses cytological, genetic and biochemical tools to investigate the regulation of the bacterial cell division protein machine. His research has contributed important insights into how the cell positions the machine, the molecular connections between the machine and the nucleoid and cytoplasmic membrane, coordination between early and late stages of cytokinesis, and how activity of the machine is regulated. Hypermorphic mutants, which bypass several normally essential cell division proteins in E. coli, have been particularly useful genetic tools for the community and should prove valuable for dissecting signaling pathways that govern cell division activity.



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