Melissa Brown

Brown Melissa 250

Research in the Brown laboratory focuses on pathogenic bacteria, analysing the means they use to defend themselves from, and evade strategies employed by, the host for their elimination. In particular we are investigating bacterial antimicrobial resistance mediated by membrane-bound transport proteins, which actively export compounds out of the cell before they can reach their intracellular target. Although evolutionarily related, these efflux pumps can either be specific for one compound or can recognise and expel a wide array of structurally-different antimicrobial agents. Additionally, we are analysing the mechanisms used by the nosocomial pathogen Acinetobacter baumannii that are involved in strategies related to resistance and resilience of this organism.