Bradley Moore

Moore Bradley 250

Moore's scientific interests focus on chemically exploring and genetically exploiting marine microbial natural products, primarily as drug leads and environmental toxins. His laboratory employs a multidisciplinary approach connecting genes to molecules, and over the years has developed numerous genome mining techniques that are now standard in the biosynthetic community. They have established metabolic pathways to numerous marine microbial compounds, including the potent oncology agent salinosporamide A, the promising antibiotic taromycin A, the coral settlement cue tetrabromopyrrole, and widespread polybrominated diphenylether environmental toxins. Their work on enzyme discovery has resulted in several new classes and reactions, especially in (de)halogenation and flavin biochemistry, that they apply as biocatalysts in complex natural product syntheses.

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