Justin Radolf

Radolf Justin 250

Justin David Radolf is Professor of Medicine, Pediatrics, Molecular Biology and Biophysics, Genetics and Genome Science, and Immunology at UConn Health and Senior Scientific Advisor to Connecticut Children’s Medical Center. The focus of his research (http://spirocheteresearch.uchc.edu/) is the pathogenesis of syphilis and Lyme disease, caused by the spirochetes Treponema pallidum and Borrelia burgdorferi, respectively. The primary goals of his syphilis research are to (i) understand the molecular architecture and function of the T. pallidum cell envelope and (ii) characterize the spirochete’s rare outer membrane proteins, both of which are central to T. pallidum’s ability to make a living as a ‘stealth pathogen’ in its obligate human host. His Lyme disease research focuses on the genetic regulatory pathways that enable B. burgdorferi to transit between and adapt to its arthropod vector and mammalian reservoir during the enzootic cycle that sustains infection of humans.