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Tuesday, 25 July 2017 09:27

N Limitation Effects on Prochlorococcus SS120 Proteome - mSystems®

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Prochlorococcus is the most abundant photosynthetic organism on Earth, contributing significantly to global primary production and playing a prominent role in biogeochemical cycles. Here we study the effects of extreme nitrogen limitation, a feature of the oligotrophic oceans inhabited by this organism. Quantitative proteomics allowed an accurate quantification of the Prochlorococcus proteome, finding three main responses to nitrogen limitation: upregulation of nitrogen assimilation-related proteins, including transporters; downregulation of ribosome proteins; and induction of the photosystem II cyclic electron flow. This suggests that nitrogen limitation affects a range of metabolic processes far wider than initially believed, with the ultimate goal of saving nitrogen and maximizing the nitrogen uptake and assimilation capabilities of the cell.

Maria Agustina Domínguez-Martín, Guadalupe Gómez-Baena, Jesús Díez, Maria José López-Grueso, Robert J. Beynon, José Manuel García-Fernández

Julie A. Huber, Editor

Published in mSystems® on 30 May 2017
Direct link: doi.org/10.1128/mSystems.00008-17

mSystems® publishes preeminent work that stems from applying technologies for high-throughput analyses to achieve insights into the metabolic and regulatory systems at the scale of both the single cell and microbial communities. The scope of mSystems® encompasses all important biological and biochemical findings drawn from analyses of large data sets, as well as new computational approaches for deriving these insights. mSystems® welcomes submissions from researchers who focus on the microbiome, genomics, metagenomics, transcriptomics, metabolomics, proteomics, glycomics, bioinformatics, and computational microbiology. mSystems® provides streamlined decisions, while carrying on ASM's tradition of rigorous peer review.

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