Candida Preliminary Program


Monday, March 22
 

7:30 pm - 9:00 pm

Joint Opening Plenary Session

7:30 pm - 9:00 pm

Coccidioides from Discovery to Phylogen, Population Gen and Transcript-omics.
John Taylor, University of Calirfornia, Berkeley

7:30 pm - 9:00 pm
Candida Research: Past, Present and Future
Frank Odds, University of Aberdeen
Tuesday, March 23  

8:15 am - 9:45 am

Session 1: Candida Genome Structure and Evolution
Chairs: Derek Sullivan and Geraldine Butler 

8:15 am - 9:45 am 

A Study on the Fates of Somatic Hybridization between Candida Albicans and Candida Dubliniensis
Kaustuv Sanyal, Jawaharlal Nehru Centre for Advanced Scientific Research

 8:15 am - 9:45 am

Reversion of CUG Identity from Serine to Leucine in Candida Albicans 
Ana Bezerra, CESAM - University of Aveiro

8:15 am - 9:45 am 

Increase of Genetic Diversity as an Adaptation Mechanism to Changing Host Environments 
David Bruck, University of Minnesota

8:15 am - 9:45 am

The Dam1 Complex, a Group of Fungal-Specific Kinetochore Proteins, is Essential for Viability in Candida Albicans 
Laura Burrack, University of Minnesota

8:15 am - 9:45 am

Candida Albicans and Candida Dubliniensis
Gary Moran, Dublin Dental School and Hospital

8:15 am - 9:45 am

Genomic Analysis of the Candida Parapsilosis Species Group
Geraldine Butler, University College Dublin

10:30 am - 12:00 pm

Session 2: Morphogenesis, Cell Cycle and Mating
Chairs: Y. Wang and Catherine Bachewich

10:30 am - 12:00 pm

The Non-Sex Genes Embedded in the MTL Locus of Candida Albicans
Thyagarajan Srikantha, University of Iowa

10:30 am - 12:00 pm

Regulation of Growth in the Gastrointestinal Tract by the Transcription Factor EFG 1 in Candida Albicans
Jessica Pierce, Tufts University

10:30 am - 12:00 pm

Discrimination of Candida Albicans Yeast from Hyphae by Oral Epithelial Cells Using the MAPK Signalling Pathway
Julian Naglik, The Dental Institute, King's College, London

10:30 am - 12:00 pm

Sexual Pheromones Drive Same-Sex Mating in Candida Albicans
Richard Bennett, Brown University
10:30 am - 12:00 pm
Regulation of Cell Proliferation and Differentiation in Candida Albicans: Unique Aspects of the G1/S Regulatory Circuit and Links to Development
Catherine Bachewich, Concordia University 

10:30 am - 12:00 pm
G1 Cyclins in the Morphogenesis of Candida Albicans
Guisheng Zeng, Institute of Molecular and Cell Biology

1:30 pm - 3:00 pm

Sessions 3: Clinical Challenges and Disease Management - Joint with Dimorphic Fungal Pathogens
Chairs: Kieren Marr and Jack Edwards

1:30 pm - 3:00 pm

Epidemiology and Antifungal Resistance Results of Current Candidemia Surveillance in Atlanta and Baltimore, US
Shawn Lockhart, Centers for Disease Control and Prevention

1:30 pm - 3:00 pm
Towards an Invitro Analysis of Chronic Vuluovaginal Candidiasis
Francisco Alvarez, Stockholm University, Wenner-Gren Institute

1:30 pm - 3:00 pm

Genetic Variants of Dectin-1 and Susceptibility to Infections with Candida spp.
Mihai Netea, Radboud University Nijmegen Medical Centre
Wednesday, March 24  
8:15 am - 9:45 am
Session 4: Strategies for New Diagnostics and Treatment - Joint with Dimorphic Fungal Pathogens
Chairs: Joseph Wheat and Luis Ostrosky Zeichner
8:15 am - 9:45 am

Serological Profiling of a Candida Albicans Protein Microarray Reveals Permanent Host-Pathogen Interplay & #38; Stage-Specific Responses During Candidemia
Brian Mochon, University of California, Irvine
8:15 am - 9:45 am 
Candida PCR of the Blood is Sensitive in Diagnosing Invasive Candidiasis Among Patients with Negative Blood Cultures
Cornelius Clancy, University of Pittsburgh
8:15 am - 9:45 am
Evidence for Experimental Horizontal Transmission of Candida Albicans and Vaccine Responses in Mice with GI-Tract Colonization with the Fungus
Jim Cutler, LSUHSC Pediatrics and Children's Hospotal

8:15 am - 9:45 am
New Diagnostics and New Approaches
Luis Ostrosky-Zeichner, University of Texas Medical School at Houston

10:30 am - 12:00 pm

Session 5: Antifungal Agents and Resistance
Chairs: Leah Cowen & Rajendre Prasad

10:30 am - 12:00 pm

Azole Drug Import Requires a Transporter in Candida Albicans and other Pathogenic Fungi
Theodore White, Seattle Biomedical Research Institute

10:30 am - 12:00 pm

Roles of Calcineurin and CRZ1 in Antifungal Susceptibility and Virulence of Candida Glabrata
Taiga Miyazaki, Nagasaki University School of Medicine

10:30 am - 12:00 pm

Drug -Target Interaction Mediates Upregulation of Multidrug Transporter Gene CDR1 in Candida Glabrata
Thomas Edlind, Drexel University College of Medicine
10:30 am - 12:00 pm

Identification of CgPdr1p-Dependent Virulence Factor(s) in Candida Glabrata
Selene Ferrari, Institute of Microbiology, University of Lausanne & University Hospital Center
10:30 am - 12:00 pm
Hsp90 Orchestrates Regulatory Circuitry Governing Drug Resistance of Candida Albicans via Calcineurin and Mkc1
Leah Cowen, University of Toronto
10:30 am - 12:00 pm

Molecular Determinants of CDR1 over-expression in Azole Resistant Clinical Isolates of Candida Albicans
Raman Manoharlal, Jawaharlal Nehru Centre for Advanced Scientific Research

1:30 pm - 3:00 pm

Session 6: Virulence Factors and Growth in Vivo
Chairs: Joachim Morschhauser and Daniel Kornitzer
1:30 pm - 3:00 pm
Candida Glabrata Survives Macrophages Phagocytosis by Inhibition of Acidification During Phagolysosome Maturation
Katja Seider, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knoell Institute 
1:30 pm - 3:00 pm
Role of Keratinocyte Growth Factor on the Virulence of Candida Albicans
Andrew Koh, University of Texas Southwestern Medical Center
1:30 pm - 3:00 pm 
ALS1 Deletion Reduces Candida Albicans Cell Size: The Relationship Between Cell Size, Delayed Filamentation in Vitro, and Virulence of the Mutant Strain in a Murine Model of Disseminated Disease
Lois Hoyer, University of Illinois

1:30 pm - 3:00 pm

The Regulation of Carbon Assimilation in Candida Albicans
Doblin Sandai, Institute of Medical Sciences, University of Aberdeen

1:30 pm - 3:00 pm

White-Opaque Switching of Candida Albicans Allows Immune Evasion in an Environment-Dependent Fashion 
Christoph Sasse, Institut fur Molekulare Infektionsbiologie

1:30 pm - 3:00 pm

Role for a Candida Albicans Whi5/NRM1 Homolog in Both Cell Cycle and Hyphal-Specific Gene Expression
Daniel Kornitzer, Technion - I.I.T
Thursday, March 25  

8:15 am - 9:45 am

Sessions 7: Environmental Signalling and Adaptive Responses
Chairs: Haoping Liu and Martine Bassilana

8:15 am - 9:45 am

MDS3, A Regulator of Colony Morphology Phenotypic Switching, is a Member of the TOR Pathway
Lucia Zacchi, University of Minnesota

8:15 am - 9:45 am

Environmrntal pH Modulation by Candida Albicans Under Glucose-Limiting Conditions
Slavena Vylkova, UTHSC Houston
8:15 am - 9:45 am
Thioredoxin Regulates Hydrogen Peroxide Signaling and Pathogenesis in the Fungal Pathogen Candida Albicans
Alessandra Da Silva Dantas, Newcastle University

8:15 am - 9:45 am

Ras1 Post-Translational Modifications Affect Signaling in Candida Albicans
Amy Piispanen, Dartmouth Medical School 

8:15 am - 9:45 am

Role of the Phosphoinositides in Fungal Polarized Growth
Robert Arkowitz, CNRS - University of Nice-Sophia Antipolis

8:15 am - 9:45 am

#35 Cant Read

10:30 am - 12:00 pm

Session 8: Biofilms and Microbial Communities
Chairs: Aaron Mitchell and Jose Lopez-Ribot

10:30 am - 12:00 pm 

Role of Fks1p and Matrix Glucan on Albicans Biofilm Resistance to an Echinocandin, Pyrimidine, and Polyene
David Andes, University of Wisconsin
10:30 am - 12:00 pm
CO2 as an Intercellular Signalling Molecule in Candida Albicans
Populations
Fritz Muhlschlegul, University of Kent
10:30 am - 12:00 pm
Cell Wall Mannosyltransferase Mutants of Candida Albicans are Deficient in Dual Species Biofilm Formation with Streptococcus Gordonii
Lindsay Dutton, University of Bristol

10:30 am - 12:00 pm

Sod5 Protects Candida Albicans Biofilms Against Miconazole-Induced Cell Death
Karin Thevissen, CMPG, Katholieke Universiteit Leuven
10:30 am - 12:00 pm

Coming Full Circle: Dispersion as an Important Step in the Candida Albicans Biofilm Life Cycle
Priya Uppuluri, UTSA

10:30 am - 12:00 pm

An Extensive Circuitry for Cell Wall Regulation in Candida Albicans
Jill Blankenship, Carnegie Mellon University

1:30 pm - 3:00 pm

Session 9: Systems Biology
Chairs: Malcolm Whiteway and Suzanne Noble
1:30 pm - 3:00 pm

Differential Metatranscriptomic Profiling for the Simultaneous Analyses of Host and Pathogen Responses During Candida Infections
Kai Sohn, Fraunhofer IGB
1:30 pm - 3:00 pm

Experimental Annotation of the Human Pathogen Candida Albicans Coding and Non-Coding Transcribed Regions Using High-Resolution Tiling Arrays
Adnane Sellam, Biotechnology Research Institute - National Research Council of Canada

1:30 pm - 3:00 pm

Transcriptome-wide Analysis of Non-Coding RNAs in Candida Albicans Guillaume Bouvet, Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal

1:30 pm - 3:00 pm

Temporal Order of Events in an Epigenetic Switch by the Fungal Pathogen Candida Albicans
Matthew Lohse, University of California San Francisco

1:30 pm - 3:00 pm 

Transcriptional Rewiring of Fungal Metabolic Pathways
Malcolm Whiteway, National Research Council of Canada
Friday, March 26  

8:15 am - 9:45 am 

Session 10: Recognition and Host Resistance (Host Responses)
Chairs: Mira Edgerton and Luigina Romani
8:15 am - 9:45 am 
Type I Interferons Modulate Host Immune Response & Outcome of Candida Infections
Olivia Majer, Max F. Perutz Laboratories
8:15 am - 9:45 am 
NLRP3 Inflammasome Activation is Critical for the Induction of Host Defenses to the Fungal Pathogen Candida Albicans
Olivia Majer, Max F. Perutz Laboratories
8:15 am - 9:45 am
CD47 Promotes Protective Immunity in a Mouse Model of Disseminated Candidiasis
Dhammika Navarathna, NCI, National Institute of Health
8:15 am - 9:45 am
Th17/IL-17 Receptor Signaling and Not Th1 cells are essential for Mucosal Host Defense Against Oral Candidiasis
Sarah Gaffen, University of Pittsburgh
8:15 am - 9:45 am
C. Albicans MSB2 is a Secreted Mucin-like Protein that Contributes to Adhesion and Virulence in Oropharyngeal Candidiasis (OPC)
S. Chadha, State University of New York at Buffalo
8:15 am - 9:45 am
Distinct Modules of Immunity Provides Protection in Candidiasis
Luigina Romani, University of Perugia
10:30 am - 12:00 pm 
Session 11: Cell Surface Biology
Chairs: Jaime Konopka and Brendan Cormack
10:30 am - 12:00 pm
Unmasking of Beta-Glucan During Infection and Treatment of Disseminated Candidiasis
Robert Wheeler, University of Maine
10:30 am - 12:00 pm
Phosphatidylserine Synthase and Phosphatidylserine Decarboxylase are Required for Cell Wall Integrity and Virulence in Candida Albicans
Anthony Montedonico, University of Tennessee
10:30 am - 12:00 pm 
Transcriptional Regulation of Candida Albicans Phosphopeptidomannan and Phospholipomannan Beta-1,2 Mannosylation Processes
Chantal Fradin, Universite Lille Nord de France 
10:30 am - 12:00 pm
Role of Als5p and Als1p Amyloid Sequences in Cell Aggregation and Binding to Plastic
Melissa Garcia, Brooklyn College
10:30 am - 12:00 pm
The C. Albicans Sur7 Plasma Membrane  Protein is Important for Morphogenesis, Intraphagosomal Growth, and Virulence 
James Konopka, Stony Brook University
10:30 am - 12:00 pm  
Systematic Analysis of Virulence Gene Regulation in Candida Glabrata
Brian Green, John Hopkins University
Wednesday, March 24  
8:00 pm - 9:30 pm 
Workshop 1: Genetic Susceptibility, Host Receptors and Interactions
Chair: Mihai Netea
8:00 pm - 9:30 pm
Insight Into the Pathogenesis of Oropharyngeal and Hematogenously Disseminated Candidiasis from Studies of Multiple Strains of Inbred Mice
Norma Solis, Los Angeles Biomedical Research Institute
8:00 pm - 9:30 pm 
Celiac Disease Patients Present High Prevalence of Antibodies Generated During Candida Albicans Infection Among which Anti-Hyphal Wall Protein 1 Profiles Parallel with Anti-Gliadinn
Daniel Poulain, Inserm 995, Lille University Hospital
8:00 pm - 9:30 pm 
A Type I-Interferon Response to Candidia spp in Innate Immune Cells May Involve Phagosomal TLR Signalling 
Christelle Bourgeois, Max F. Perutz Laboratories, Medical University of Vienna
8:00 pm - 9:30 pm
Intact Glycosylation of Candida Albicans-Derived Cell Wall Proteins is Responsible for Innate Immune Response and Apoptosis Induction in Human Oral Epithelial Cells
Jeanette Wagener, Eberhard-Karls-University Tuebingen

8:00 pm - 9:30 pm

Workshop 2: Models of Fungal Pathogenesis
Chair: Petros Ligoxygakis
8:00 pm - 9:30 pm
Influence of Candida Albicans Morphology on Tissue Damage and Local Host Response in Tissue Models of the Human Oral and Vaginal Mucosa
Sarah Bubeck, UTSA
8:00 pm - 9:30 pm
Development and Characterisation of a Novel in Vitro Oral Epithelial Model System for Examining Mechanisms of Oral Candidosis
Nishant Yadev, University of Sheffield
8:00 pm - 9:30 pm  
Influence of Candida Albicans Morphology on Tissue Damage and Local Host Response in Tissue Models of the Human Oral and Vaginal Mucosa
Sarah Bubeck, UTSA
8:00 pm - 9:30 pm   
Neonatal Mouse Model for Disseminated Candidiasis
Nancy Tsai, Women & Infants Hospital, Brown University
8:00 pm - 9:30 pm   
Establishment of a Contemporary Rat Model of Candida-Associated Denture Stomatitis to Evaluate the Role of Biofilm in Disease
Clorinda Johnson, LSU Health Sciences Center
8:00 pm - 9:30 pm  
Assaying Virulence of Candida Clinical Strains Using Drosophila Melanogaster as the Model Host
Petros Ligoxygakis, University of Oxford
8:00 pm - 9:30 pm 
Workshop 3: Other Fungal Species
Chair: Alejandro De Las Penas
8:00 pm - 9:30 pm  
Comprehensive Gene Deletion Study to Identify Cell Wall Organisation and Structure in Candida Glabrata
Ekkehard Hiller, Fraunhofer IGB
8:00 pm - 9:30 pm  
Concerted Evolution of Candida Krusei Multidrug Efflux Pumps ABC1 and ABC11 - A Highly Homologous Pair of Tandem-Duplicated Genes Erwin Lamping, University of Otago School of Dentistry
8:00 pm - 9:30 pm
The Roles of Candida Glabrata Ste11p and Hog1p in the Transcriptional Response to Hyperosmotic Stress
Ken Haynes, Imperial College
8:00 pm - 9:30 pm 
Comprehensive Gene Deletion Study to Identify Cell Wall Organisation and Structure in Candida Glabrata
Ekkehard Hiller, Fraunhofer IGB
8:00 pm - 9:30 pm   
The Oxidative Stress Response in Candida Glabrata
Alejandro De Las Penas, Instituto Potosino de Investigacion Cientifica y Tecnologica

8:00 pm - 9:30 pm

Workshop 4: Cool Tools for Candida
Chair: Carol Munro
 
8:00 pm - 9:30 pm
 
Watching Candida in Action: Imaging Albicans Infections in Live Mice
Melanie Wellington, University of Rochester

8:00 pm - 9:30 pm
 
Development and Evaluation of a Candida Two-Hybrid System
Bram Stynen, Katholieke Universiteit Leuven
8:00 pm - 9:30 pm
Probing Calcium Homeostasis in Candida Albicans with an Aequorin-Based Bioluminescence Assay
Dominique Sanglard, Institute of Microbiology, University of Lausanne
8:00 pm - 9:30 pm  
Creation and Phenotypic Profiling of a Tagged Transposon Mutant Collection of Candida Albicans
Julia Oh, Stanford University

8:00 pm - 9:30 pm

Identification of Antifungal Protein Kinase Inhibitors by Synthetic Genetic Interaction-Guided Chemical Genetic Screening
Damian Krysan, University of Rochester 

8:00 pm - 9:30 pm

The Candida Albicans ORFeome Project
Audrey Nesseir, Institut Pasteur

8:00 pm - 9:30 pm

Workshop 5: Fungal Dimorphism and Pathogenesis
Chair: David Kadosh & Alex Andrianopoulos

8:00 pm - 9:30 pm

RSR1 is Important for Retention of Polarity Proteins at Hypal Tips During Septation
Rebecca Pulver, University of Minnesota 

8:00 pm - 9:30 pm

Catalytic Isoforms TPK1 and TPK2 of Candida Albicans PKA have Non- Redundant Roles in Stress Response, Glycogen Metabolism, Pseudohyphal Elongation, Cell Adherence and Biofilm Formation Romina Giacometti, Inba-Conicet

8:00 pm - 9:30 pm

From Attachment to Damage: Defined Factors and Activities of
Candida Albicans Mediate Adhesion, Invasion or Damage During Interaction with Oral Epithelial Cells  
Betty Wachtler, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institue Jena
8:00 pm - 9:30 pm 
A Genomic Dissection of the Candida Albicans Yeast-Pseudohypal-Hyphal Transition
David Kadosh, University of Texas Health Science Center at San Antonio

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