MCR-1 GENE ISOLATEDMCR-1 gene isolated from human for first time in Brazil.
Dr. Rice's laboratory studies molecular mechanism involved in virus-host cell interactions. During the past several years, they have focused on HIV-1 and have been particularly interested in host cell proteins that the virus utilizes to mediate viral gene expression in CD4+ cells and macrophages, the two major cell types targeted by HIV-1 infection in vivo. Dr. Rice and his lab are particularly interested in studying the function of these cellular proteins in normal cellular physiology and how these functions might be perturbed by HIV-1 to enhance viral replication. Additionally, they have recently begun to study molecular mechanisms of virus-host cell interactions in influenza virus infection.