The Zika ThreatASM Acts to Counter Zika Virus Outbreak.
Dr. Beemon's laboratory has identified and studied several RNA elements within the avian retroviral genome/unspliced RNA, which regulate its splicing, polyadenylation, and export. She is currently focusing on an RNA stability element that she has identified downstream of the gag termination codon. It appears to protect the full-length retroviral RNA from nonsense-mediated RNA decay. She is studying its mechanism of action and think it may be significant for other viral and cellular mRNAs, as well. In addition, she is studying oncogenesis induced by avian leukosis viruses (ALV). Dr. Beemon has found clonal proviral integrations upstream of the TERT gene, suggesting its expression may be an early event in tumorigenesis. She and her laboratory are also exploring how retroviral activation of bic (miR-155 precursor) is important in oncogenesis in tumors induced by ALV and by reticuloendotheliosis virus.