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Dr. Bonomo's laboratory studies the genetic and biochemical basis of beta-lactam resistance mediated by beta-lactamases and penicillin binding proteins in Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. To these ends he is interested in beta-lactam antibiotics and beta-lactamase inhibitors as novel therapeutics. He has also explored structure-function relationships of SHV and KPC beta-lactamases with BLIP, the beta-Lactamase Inhibitory Protein. Recent work is focused on novel approaches to understanding the molecular epidemiology and rapidly detecting multidrug-resistant (MDR) Acinetobacter baumannii and carbapenem resistant Klebsiella pneumoniae. In addition, he is interested in the complex genetic background and genome sequence of MDR A. baumannii, extended-spectrum beta-lactamase and carbapenem resistant K. pneumoniae. Dr. Bonomo's lab also seeks to apply molecular diagnostics to define the transmissibility and resistance profile of S. aureus.