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The primary interest of Dr. Brown's laboratory is macrophage receptors and their role in immunity and homeostasis. Dr. Brown is particularly interested in the C-type lectin receptors found in the "Dectin-1" and "Dectin-2" clusters located in the natural killer gene complex. These receptors have been shown to play essential roles in immunity to a variety of pathogens, including fungi, mycobacteria and helminths, and have also been implicated in homeostasis, through the recognition of necrotic cells, for example. Much of the work in Dr. Brown's laboratory has been focussed on Dectin-1, the major receptor for beta-glucans on myeloid cells. Importantly, Dr. Brown and others have shown that C-type lectins are capable of inducing numerous cellular responses as well as innate inflammation, and the development of adaptive immunity.