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There are two very different transcriptional states of the HSV genome. In one state the genome is transcribed in an ordered cascade such that the approximately 85 gene products are abundantly synthesized leading to the prolific production of progeny virions and cell destruction. By contrast transcription can be repressed, such that very little if any viral gene products are made, resulting the long-term persistence of the viral genome. Dr. DeLuca's laboratory studies the viral and cellular mechanisms involved in these two different transcriptional states, as well as the mechanisms affecting the transition between them.