zika

Congress Passes Zika Funding Bill

Congress passed and President Obama signed a 10-week continuing resolution, which includes $1.1 billion for Zika virus research.
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ASM Acts to Counter Zika Virus Outbreak

The emerging threat of Zika virus infection.
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ASM Urges Action to Combat Zika Emergency

Current events linked to the Zika virus make aggressive public health actions and funding to combat this emerging infectious disease more crucial than ever.
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Jacobson_AllanResearch in the Jacobson laboratory is focused on cytoplasmic aspects of post-transcriptional regulation, namely translation termination, nonsense-mediated mRNA decay (NMD), and therapeutic nonsense suppression. Work from the lab indicates that premature and normal termination differ mechanistically, with premature termination being a relatively inefficient process that leads to the ribosomal recruitment of at least three key regulatory proteins (Upf1, Upf2/Nmd2, and Upf3). These factors appear to play a role in both the triggering of NMD and the dissociation of the premature termination complex. Current studies are attempting to: a) define the timing and interaction-dependencies of Upf1, Upf2/Nmd2, and Upf3 association with prematurely terminating ribosomes, b) evaluate the functional differences of normal vs. premature termination, and c) elucidate several different mechanisms by which a near cognate tRNA can be inserted into a ribosomal A site programmed with a nonsense codon. The latter process, nonsense suppression, is of particular interest as a potential pathway to treatment of the large number of human genetic disorders attributable to nonsense mutations.

 

Website: http://www.umassmed.edu/MaPS/faculty/jacobson.cfm

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