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ninfa alexanderDr. Ninfa studies signal transduction mechanisms of bacteria, and also studies the functions of genetic networks using a synthetic biology approach. His studies of signal transduction mechanisms are focused upon the systems responsible for controlling nitrogen assimilation in E. coli; these include a two-component system, the PII protein that serves as a sensor of nitrogen status and cellular energy charge, and two systems of linked covalent modification cycles (bi-cyclic cascades) that mediate the short-term and long-term adaptations to changes in nitrogen availability. His synthetic biology studies are focused on creating oscillating or bistable genetic systems, such as a synthetic genetic circadian clock for E. coli and a family of genetic toggle switches.

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