rosen hughDr. Rosen is Professor of Chemical Physiology at The Scripps Research Institute. He received his M.D. from the University of Cape Town and his Ph.D. from Oxford. His laboratory uses chemical approaches to define control points in immune function that shed light on mechanisms and treatments for autoimmunity and viral immunopathology. Work with colleagues Michael Oldstone, Ray Stevens and Ed Roberts has led to the discovery of chemical agonists and antagonists for the sphingosine 1-phophate receptor system that has defined a new chemically-tractable mechanism for the amelioration of influenza immunopathology, a high resolution crystal structure of the S1P1 receptor, and a potential treatment for multiple sclerosis now in Phase I clinical studies that derived from a lead discovered in the NIH Compound Repository, part of the Molecular Libraries Initiative of the NIH Roadmap (


The labs activities can be found at and the activities at the Scripps Research Institute Molecular Screening Center at