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Dr. Spindler studies the contributions of both viral and host genetics to the pathogenesis of mouse adenovirus type 1 infection. Depending on the virus strain, mouse strain, and dose of virus, mice will either succumb to encephalitis or survive and be persistently infected. She is also interested in the pathogenesis and host genetics of susceptibility to bunyaviruses, including Punta Toro virus, an RNA virus closely related to Rift Valley fever virus, a serious human pathogen. Dr. Spindler has a long-standing interest and has been active in increasing diversity in microbiology from the undergraduate to the faculty level.