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Dr. Andersson's research addresses the mechanisms and dynamics of molecular evolution in bacteria and how factors such as supply and type of genetic variation, strength of selection and compensatory mutations affect the tempo and mode of adaptive evolution in response to, for example, the presence of antimicrobial drugs.
The long‐term goal of his research is to identify and examine the major factors that influence the tempo and mode of bacterial evolution and, in particular, evolution of antibiotic resistance. He studies these problems in several bacterial species using a combination of methods, including experimental evolution, bacterial genetics, molecular biology, biochemistry, and mathematical modeling. At present his research is focused on the dynamics of antibiotic resistance development, the importance of deleterious and compensatory mutations in evolution, physiological mechanisms that buffer the negative effect of deleterious mutations, evolution of new genes, constraints on horizontal gene transfer and mechanisms of reductive genome evolution.