andrews brenda

Dr. Andrews' current research interests include mechanisms of cell cycle control and the regulation of cell cycle-dependent transcription, kinase specificity and function, and regulation of cell polarity and morphogenesis.  Although her lab is particularly interested in these biological processes, they have a broader functional genomics program, based on an automated genetics platform that we developed in collaboration with the Boone laboratory.  Dr. Andrews' lab has established a unique array-based method for mapping genetic interaction networks in budding yeast called Synthetic Genetic Array or SGA analysis. The ultimate goal of their project is to generate a comprehensive genetic interaction network for a basic eukaryotic cell.  They have also expanded their automated yeast genetics to include a comprehensive study of second site suppressors and gene overexpression effects; this effort will be coupled with a new high through-put cell biology platform to allow phenotypic measurement on a large scale.  The lab's current large scale projects include genome-wide Synthetic Dosage Lethal screens to discover targets for protein kinases, and systematic assays of tagged reporter genes to delineate transcriptional regulatory pathways.






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