Dr. Nizet is a Professor of Pediatrics and Pharmacy at the University of California, San Diego and Chief of the Division of Pediatric Pharmacology & Drug Discovery at UCSD School of Medicine and Skaggs School of Pharmacy & Pharmaceutical Sciences. Dr. Nizet received his medical training at Stanford University School of Medicine, completed a Residency and Chief Residency in Pediatrics at Harvard University's Children's Hospital in Boston, Massachusetts, and a Fellowship in Pediatric Infectious Diseases at the University of Washington's Children's Hospital in Seattle.
The interest of the Nizet Laboratory lies in understanding fundamental mechanisms of bacterial pathogenesis and the innate immune system, with a special focus on human streptococcal and staphylococcal infections. Using a molecular genetic approach, the laboratory seeks to discover and characterize bacterial virulence determinants involved in cytotoxicity, adherence, invasion, inflammation, molecular mimicry and resistance to immunologic clearance. In companion studies, they investigate the contribution of host factors such as antimicrobial peptides, leukocyte surface receptors, signal transduction pathways, and transcription factors in defense against invasive bacterial infection. Ultimately, they believe the basic information gained through this platform will lead to novel treatment strategies for infectious diseases, involving targeted neutralization of bacterial virulence phenotypes and pharmacologic augmentation of host innate immune function.
More information can be found on the laboratory website: http://nizetlab.ucsd.edu