https://www.asm.org/modules/mod_image_show_gk4/cache/mSphere Direct herogk-is-651.pnglink
https://www.asm.org/modules/mod_image_show_gk4/cache/Podcast Hero Banner3gk-is-651.pnglink
https://www.asm.org/modules/mod_image_show_gk4/cache/Microbe Online Program Plannergk-is-651.pnglink
https://www.asm.org/modules/mod_image_show_gk4/cache/AAAS Fellows Bannergk-is-651.jpglink
https://www.asm.org/modules/mod_image_show_gk4/cache/Read New JMBE Bannergk-is-651.jpglink
0 1 2 3 4
Progress bar
16-01-2017mSphere Direct
16-01-2017Podcast banner
16-01-2017AAAS Fellows
16-01-2017Read new JMBE
Become a member today!
JOIN/RENEW
Submit to an ASM Journal
SUBMIT
Attend ASM Biothreats Meeting
REGISTER

patton john

 

The Patton laboratory studies rotaviruses, etiological agents that represent the primary cause of severe dehydrating diarrhea in infants and young children. Globally, rotavirus infections result in nearly 500,000 deaths each year, with the vast majority occurring in developing countries. Despite their pathogenic importance, many of the fundamental events in the replication cycle of these segmented double-stranded RNA (dsRNA) viruses are not understood. An overall mission of the Patton laboratory is to acquire knowledge about the molecular biology, immunology, and epidemiology of rotaviruses that can be applied to developing methods for preventing and treating rotavirus disease. The current aims of the laboratory are to (i) elucidate the structures, functions, and interactions of viral proteins involved in viral genome packaging and replication, (ii) describe the pathway by which rotaviruses antagonize host cell interferon responses, (iii) characterize the diversity and evolutionary dynamics of circulating human rotaviruses, and (iv) develop reverse-genetic strategies to aid studies of rotavirus biology and to create live-attenuated vaccine candidates.

 


 

TPL_asm2013_SEARCH

91256