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Despite over a century of research, Mycobacterium tuberculosis remains one of the leading causes of infectious death in the world. While treatments are available, they are difficult to administer for the extended times required for cure and, therefore, are far from optimal. Dr. Eric Rubin's lab studies the factors required for mycobacteria to survive and grow, both under artificial conditions and during model infections. They have devised a number of genetic approaches to identifying cellular consittuents required for optimal growth and to study individual essential genes and their products. They continue to explore basic mycobacterial cell biology, including cell division, translation and protein turnover, and the interface between the pathogen and its host.