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The Zychlinsky lab proposes the hypothesis that the multitude of diseases is based on only a limited number of molecular pathways. This is why they work on very different diseases which are caused either by an infection or by an endogenous stimulus. One part of the lab works on the Type III secretion system and aims at understanding structurally how pathogens deliver proteins to the host cell which enables them to start the infection. Another group is interested in how the immune system measures the danger and regulates the answer through the inflammasome. Finally, they try to understand the role of neutrophils and one of their antimicrobial mechanisms - Neutrophil Extracellular Traps (NETs). These are not only crucial for fighting infections but also may trigger autoimmune responses.
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