Media Advisory: Rescue of the 1947 Zika Virus Prototype Strain with a CMV Promoter-Driven cDNA Clone
Washington, DC – September 28, 2016 – Researchers have created a model system of Zika virus to study how the genetics of zika virus impact viral replication and pathogenesis. A new study in the American Society for Microbiology’s open-access journal mSphere describes this new model. Researchers created a plasmid encoding the prototype 1947 Uganda MR766 Zika virus genome that could produce high levels of infectious virus in mammalian cells through direct delivery of this DNA. The study of Zika virus has become increasingly important, and would benefit from an efficient strategy to genetically manipulate the virus. The model provides a simple and effective means to study the pathogenesis of Zika virus and offers an efficient strategy to manipulate the virus.
Study by 2016 MacArthur Genius Grant Winner Advances the Direct Study of Microbial Communities in Diverse Environments, Including Those in Mammalian Systems
Washington, DC – September 27, 2016 – For researchers to effectively identify novel therapeutic approaches to chronic bacterial infections, an understanding of how microbes survive in vivo is needed. A study published in ASM’s open-access journal, mBio, looks at The tissue-clearing technique, MiPACT, designed to retain and visualize bacteria, can be coupled with hybridization chain reaction (HCR) to detect rRNA in the sputum samples from cystic fibrosis. The researchers, led by Dianne Newman, a MacArthur ”Genius” Grant Winner, have demonstrated MiPACT’s ability to survey thousands of bacteria (or bacterial aggregates) over millimeter scales and quantify aggregation of individual species in polymicrobial communities.
Researchers Sequence Genome from 1979 Russian Anthrax Outbreak
Washington, DC – September 27, 2016 – Analyzing small pieces of tissue from nearly 40-year-old human autopsies, Arizona researchers have sequenced the genome of the strain of Bacillus anthracis that caused a deadly anthrax outbreak in Russia in 1979. The work is published this week in mBio®, an online open-access journal of the American Society for Microbiology.
Potentially Life-Threatening Fungus Found In Water Distribution Systems of Five French Hospitals
Washington, DC – September 23, 2016 - A specific strain of the fungus, Fusarium oxysporum, circulates in the water distribution systems of five French hospitals, in two widely separated cities. This microbe is potentially a life-threatening risk to immunocompromised patients. The research is published September 23, 2016 in Applied and Environmental Microbiology, a journal of the American Society for Microbiology.
β-lactamase Antimicrobial Resistance Gene Found In Marine Pathogen
Washington, DC – September 19, 2016 – A team of Chinese investigators has discovered a gene for resistance to β-lactamase antibiotics, in the pathogenic marine bacterium, Vibrio parahaemolyticus. The β-lactamase gene, blaVEB-2, has never before been found in V. parahaemolyticus, and in fact, has been found almost exclusively in non-marine pathogens. The research is published Monday, September 19, 2016 in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology.
Protein Synthesis, ATP Unnecessary for Bacterial Spore Germination
Washington, DC - September 19, 2016 - Spores of Bacillus bacteria can survive for years in a dormant state, and then germinate in minutes. But it has long been unclear whether germination required protein synthesis, or cellular energy packets, which are known as ATP. Now, a team from UConn Health, Farmington, CT, has shown that neither is necessary. The research is published online September 19 in the Journal of Bacteriology, published by the American Society for Microbiology.
Microbes Corrode Steel in Ships, Marine Infrastructure
Washington, DC - September 16, 2016 - Rust is the bane of steel, whether on cars, on ships and boats, or as part of marine infrastructure. Now, contrary to previous thinking, it turns out that the ocean-dwelling, steel-corroding species, Mariprofundus sp. DIS-1, can thrive under aerobic conditions, rather than being limited to “micro-aerobic” or anaerobic conditions. That means steel in marine environments is more vulnerable to bacterial depredations than previously thought. The research is published on Friday, September 16th in Applied and Environmental Microbiology, a journal of the American Society for Microbiology.
Molecules Released by Klebsiella pneumoniae Bacterium Pave the Way for Invasive Infection
Washington, DC – September 13, 2016 – It’s been known that the bacterium Klebsiella pneumoniae secretes small molecules called siderophores that enable it to acquire iron from a host and fuel its spread. Now, Michigan researchers have found that these molecules play additional roles in helping the organism invade. Their report is published this week in mBio®, an online open-access journal of the American Society for Microbiology.
Chinese Investigators Characterize the World of Resistance Gene Exchange Among Bacteria
Washington, DC – September 9, 2016 – Certain antibiotic resistance genes are easily transferred from one bacterial species to another, and can move between farm animals and the human gut. A team led by Chinese researchers has characterized this “mobile resistome,” which they say is largely to blame for the spread of antibiotic resistance. They found that many antibiotic resistance genes that are shared between the human and animal gut microbiome are also present in multiple human pathogens. These findings are published September 9 in Applied and Environmental Microbiology, a journal of the American Society for Microbiology.
Fungi Contribute to Delayed Healing of Chronic Wounds
Washington, DC – September 6, 2016 – Researchers in Pennsylvania and Iowa have discovered that fungal communities found in chronic wounds can form mixed bacterial-fungal biofilms and can be associated with poor outcomes and longer healing times. Their report, the first deep characterization of the fungi found in diabetic foot ulcers, is published this week in mBio®, an online open-access journal of the American Society for Microbiology.