C. difficile Needs Iron, But Too Much Is Hazardous: New Insights Into Maintaining It “Just Right”

Washington, D.C. - July 6, 2015 - Those bacteria that require iron walk a tightrope. Iron is essential for their growth, but too much iron can damage DNA and enzymes through oxidation. Therefore, bacteria have machinery to maintain their intracellular iron within the “Goldilocks zone.” Now Theresa D. Ho, PhD, and Craig D. Ellermeier, PhD shed new light on how the pathogen, Clostridium difficile, which is the most common cause of hospital-acquired infectious diarrhea, regulates iron. The research is published online ahead of print July 6 in the Journal of Bacteriology, a publication of the American Society for Microbiology.

Infection With Wolbachia Bacteria Curbs Fighting Among Fruit Flies

Washington, D.C. - July 2, 2015 - Male fruit flies infected with the bacterium, Wolbachia, are less aggressive than those not infected, according to research published in the July Applied and Environmental Microbiology, a journal of the American Society for Microbiology. This is the first time bacteria have been shown to influence aggression, said corresponding author Jeremy C. Brownlie, PhD, Deputy Head, School of Natural Sciences, Griffith University, Brisbane, Australia.

Human Urine Helps Prevent Bacteria from Sticking to Bladder Cells

Washington, D.C. —June 30, 2015—Human urine contains factors that prevent a common culprit in urinary tract infections (UTIs), uropathogenic Escherichia coli bacteria, from properly attaching to bladder cells, a necessary step for infection. The research, published this week in mBio, the online open-access journal of the American Society for Microbiology, reveals a weakness that could be exploited to develop more effective, non-antibiotic treatments for UTIs.

Hantaviruses Are Highly Dependent on Cell Membrane Cholesterol to Gain Entry, Infect Humans

Washington, D.C. – June 30, 2015 – Hantaviruses use cholesterol in cell walls to gain access into cells and infect humans, according to laboratory research published this week in mBio®, the online open-access journal of the American Society for Microbiology.

In ERs, Urinary Tract and Sexually Transmitted Infections In Women Misdiagnosed, Even Mixed Up Nearly Half the Time

Washington, D.C. - June 24, 2015 - Urinary tract and sexually transmitted infections in women are misdiagnosed by emergency departments nearly half the time, according to a paper in the Journal of Clinical Microbiology, a publication of the American Society for Microbiology. These misdiagnoses result in overuse of antibiotics, and increased antibiotic resistance, according to Michelle Hecker, MD, an assistant professor in the Department of Medicine, Division of Infectious Diseases, MetroHealth Medical Center, Case Western Reserve University, Cleveland, and her collaborators.