Julie Wolf

Julie Wolf

ASM Communications Social Media Specialist Julie Wolf spent her research career focused on medical mycology and infectious disease. Broadly interested in microbiology and scientific communication, she has taught at Long Island University and the community biolab Genspace and has written for the Scientista Foundation and Scholastic’s Science World magazine. Follow her on Twitter for more ASM and Microbiology highlights at @JulieMarieWolf.

Near Kisameet Bay on the central coast of British Columbia sits a deposit of clay that covers 5 acres and spans a depth up to 42 feet in places. This vast smear formed 10,000 years ago as glacial melt filled a granite basin and fine minerals silted out.

The previous post mentioned the onset of antibiotic resistance as one of the scarier, if less sensationalist, outbreaks of our time. We generally discuss antibiotic resistance in medically relevant microbes (on this blog and in the news), where resistance means the ability of disease-causing microbes to grow in the presence of a drug that previously prevented, or at least slowed microbial reproduction.

Drug-resistant infections are becoming one of the scariest epidemics since the advent of antibiotic discovery. Although microbes like methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci*, and multidrug-resistant Pseudomonas aeruginosa are responsible for 23,000 deaths in the US alone, they don’t garner the headlines of a disease like Ebola, which although clearly a devastating outbreak in Africa, affected far fewer people within North America.

Imagine taking an ocean-side vacation, with the sun, sand, and water lulling you to relaxed bliss. After day at the beach, you experience an intense bout of stomach cramps and – more delicately put – GI distress. A rare day off is ruined because of a bug you picked up. Next, imagine a situation where a task as innocuous as drinking tap water sends you running to the nearest bathroom. Even worse, imagine a situation where an entire town experiences simultaneous diarrhea from contaminated tap water.

Feeling a bit under the weather? There’s a decent chance you’re suffering from an infection with an enterovirus. Enteroviruses are a commonly encountered virus, especially in the summer and fall. They can cause a variety of symptoms, from cold-like symptoms such as runny nose or fever to more serious sequelae such as meningitis or encephalitis. In 2014, an outbreak of enterovirus D68 correlated with nearly 100 cases of acute flaccid paralysis, though no specific cause has been identified (and there are additional viruses also under investigation). Most people infected with enteroviruses experience only mild, if any, disease, but those who suffer severe cases illustrate the importance of developing treatments for this disease.

As we’ve seen in numerous cases in 2015, food contamination is a real issue for a number of different food types. Vegetable, meat, packaged, fresheven pet food – we’ve seen too many examples of how bacteria can outsmart our best food safety practices. The Canadian government estimates 1 of every 8 Canadians experiences food-borne illness each year, leading to 11,600 hospitalizations and 238 deaths. As we’ve often discussed on this blog, a common culprit for food contamination is Listeria monocytogenes, in part because of Listeria’s ability to grow in food storage conditions.

Monday, 04 January 2016 10:48

Cyclic-di-GMP takes center stage

How does a single-celled organism ‘know’ how to respond to its environmental conditions? Understanding microbial cell signaling is one way to determine how bacteria will react in a particular setting. In the past decade, researchers have revealed a significant role for cyclic-di-GMP in bacterial signaling – so much so that the Journal of Bacteriology has devoted its first issue of the year to summarizing a recent conference on cyclic-di-GMP discoveries.

Tuesday, 29 December 2015 10:34

Looking back at 15 top stories from 2015

In June 2015, mBioblog became mBiosphere, expanding its scope to all of the research journals published by the American Society of Microbiology. To commemorate the end of the year, we’d like to highlight our most popular stories since the switch. The below stories are fifteen of the top stories from 2015 (post-mBiosphere) – how many do you remember?

Regular readers will know that infectious disease issues often land the top billing in microbial news. However, most of our microbial interactions do not negatively impact our health – in fact, some interactions even lead to health improvements. The microbes that lead to these beneficial interactions are called probiotics. These probiotic microbes can be found in many niches of the body, but are most commonly studied with respect the gut microbiome. There, probiotic effects can range from stimulating or regulating the immune system, to promoting healthy division of mammalian cells, to stimulation of nutrient absorption and digestion. Some of the best-studied probiotics are the Lactobacillus and Lactococcus bacteria*. Two papers published this week answer some fundamental questions about these bacteria as probiotics. These findings will affect both current and future utilization of probiotics.

Monday, 14 December 2015 10:31

Albumin enhances antifungal drug activity

How do we know the effective dose of antibiotics? Despite considering factors such as infection site, body weight, and age, there is a bit of unknown with each administration, since each individual reacts differently through the complexity of so many interacting variables. Additionally, each infection site is unique, with various oxygen levels, antimicrobial peptide production, and immune cell infiltrate affecting the host-microbe interactions. Finally, factors unique to each drug must be considered, including half-life, toxicity, and specificity.

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