mBiosphere

Many drugs that target rotavirus viroplasms – centers of viral replication and assembly – target host factors, like microtubule assembly or proteasome activity. A new Journal of Virology study identifies a drug that disrupts viroplasms by targeting a viral protein. This interaction may lead to new drug discovery for rotavirus therapies.
A recent Antimicrobial Agents and Chemotherapy study undertook a meta-analysis of data from around the world to better identify common risk factors for carbapenem-resistent Enterobacteriaceae infection - and to identify ways to control outbreaks.
Scott Kelley's advice for those new to computational biology? "Don’t be afraid! Relax and enjoy the puzzle-like nature of bioinformatics!" Kelley has co-authored a new ASM Press textbook that breaks algorithms down to their basic elements. ASM interviewed him to understand his inspiration behind the textbook.
Thursday, 21 December 2017 11:23

In Case You Missed It - top 2017 mBiosphere posts

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The most popular posts here at mBiosphere this year covered the influence of the microbial sciences research on food preparation, infectious disease management, emerging diseases, and immune influence – truly illustrating the broad reach of microbiology!   
For over 100 years, Histoplasma capsulatum was thought to be a single fungal species with several variant strain variations. New analyses of genome sequences reveal the genus Histoplasma contains at least four species, and may contain more.
A cure for HIV infection remains elusive. A new model to study HIV reactivation in quiescent cells, described in Journal of Virology, may help researchers better understand infection and devise effective treatment strategies.
Persistence, like antibiotic resistance, can lead to drug failure when treating bacterial infections. A new Antimicrobial Agent and Chemotherapy study extends previous findings that a drug-metabolite cocktail may increase drug efficiency when treating Pseudomonas aeruginosa. 
Microbiology-related research is almost inevitably tied to improving public health, but some research is more immediately applicable than others. How do the microbial sciences improve public health? We list some of the many ways, and invite you to share your examples 
Wednesday, 15 November 2017 12:32

ASM Resources During Antibiotic Awareness Week

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The American Society of Microbiology is a natural resource for clinical practitioners, researchers, and educators during Antibiotic Awareness Week. Here we share some of our recent top stories on antibiotic awareness, education, discovery, and resistance.
Reporting the sex of mice and cell lines used in studies can help researchers determine if biological sex is a variable in disease outcome, argues Sabra Klein in an mBio editorial.
Microbiome studies have long focused on the bacterial members that reside in different areas of the human body. A new study from mBio shows that a tweaked protocol can better identify archaeal microbiome members too. Learn which findings surprised senior scientist Christine Moissl-Eichinger on mBiosphere.
Friday, 03 November 2017 16:21

How can chicken gut microbiomes affect human health?

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People can contract campylobacteriosis by eating contaminated chickens, and a new Infection and Immunity study demonstrates the chicken microbiome influences C. jejuni colonization. mBiosphere summarizes and discusses what this may mean for human campylobacteriosis cases.
Mutations that arise naturally are generally thought to require selection to become part of a population. A new Antimicrobial Agents and Chemotherapy study challenges that thought, by demonstrating the evolution of drug resistance in bacterial lineages never exposed to drugs. This study demonstrates the importance of stewardship in all cases, both transmission of already-resistant strains or selection for newly adapted strains.
Who develops disease and who doesn’t? In a new Journal of Virology report, scientists investigate why some young adults develop infectious mononucleosis when they contract Epstein-Barr virus and why some have an asymptomatic infection. 
Drug resistance is a huge clinical problem, but our exposure to drug-resistant bacteria can come from everyday interactions - even in our food! Two reports from Antimicrobial Agents and Chemotherapy describe new bacterial isolates carrying plasmid-borne drug resistance determinants. 
How does Plasmodium falciparum get into its host red blood cell? A new Infection and Immunity study reports the importance of a previously poorly-characterized receptor, glycophorin B (GPB), in the hierarchy of malaria invasion strategies. 
Dr. Victor J. Torres was born in Puerto Rico and received his degree in Industrial Microbiology from the University of Puerto Rico, Mayaguez campus. An editorial by Torres calls for compassion and aid for the scientific Puerto Rican community following the devastation wrought by Hurricane Maria. 
Scientists have many options for where to publish their microbiology research. A recent mBio editorial emphasizes the importance of publishing in society journals as a way to reinvest in the society and thus the scientific community. This post expands on the programs offered by scientific societies, which have their costs offset in part by their publications.
The efforts of antibiotic stewardship campaigns are starting to show positive results in the clinic. These trends can serve as motivation to all to continue education campaigns for appropriate use of antibiotics.
Can the microbiome be used for forensic purposes? The skin microbiome is fairly stable, and a new Applied and Environmental Microbiology report assesses the use of genetic markers in the skin bacterium Proprionibacterium acnes for human identification purposes. 

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