Microbe, Second Edition

Microbe2e pageheader3


Click HERE to reserve your exam copy now!  


Authors:  Michele Swanson, University of Michigan; Gemma Reguera, Michigan State University; Moselio Schaechter, San Diego State University; Frederick Neidhardt, University of Michigan


Bring the excitement, breadth, and power of the modern microbial sciences to the next generation of students and scientists in a fun and engaging way.


Microbe, Second Edition, represents an exciting collaboration between the American Society for Microbiology (ASM) Education Board and ASM Press to revise the undergraduate textbook Microbe.  The resulting edition builds on the foundation of the ASM Recommended Curriculum Guidelines for Undergraduate Microbiology Education. 


With this new edition, the goal has been to emphasize concepts, not facts.  Throughout the book, the authors integrate key concepts, learning outcomes, and fundamental statements from the Curriculum Guidelines. 




Click to view Microbe, 2e sample materials:

Front Matter and Table of Contents

Chapter 1

Chapter 5

Microbial Ecology Compiled Sample Materials 

Microbial Pathogenesis Compiled Sample Materials




To illustrate the impact of key microbiology concepts on real world scenarios, each chapter begins with a case study, ranging from sauerkraut fermentation to the cholera outbreak in Haiti. Throughout the book, questions are posed to introduce the next key concept and to prompt students to apply the concepts they are learning.

To deepen students’ understanding of both the principles and practice of science, each chapter includes multiple active learning exercises for individuals or groups, as well as vetted visual, audio, and written resources for students and faculty alike.


Microbe, Second Edition, is a valuable tool for both instructors who are teaching a traditional lecture format and those who emphasize active learning in their classroom.  This text is intended for use in microbiology courses for majors and pre-health professionals, or for scientists whose fields interface with the microbial sciences, including engineers, computational biologists, and chemists.





Features of the new Second Edition:

  • Concepts of evolutionary biology are woven throughout the text.
  • An entirely new section teaches principles of infectious diseases (6 chapters total).
  • ASM's Microbiology Education Curriculum Guidelines are used to frame the key concepts taught in each chapter.
  • Active learning exercises support instructors who “flip” their classroom.
  • Every chapter begins with a case study that brings the microbiology to life and ends by tying key concepts back to the case study.
  • Each section begins with the over-arching question that will be explored.
  • Key concepts are illustrated by a greatly expanded set of figures, animations, graphs, and tables.
  • Adopters receive the full set of images and tables as well as answers to the discussion questions at the end of chapters.




“This is a fantastic text! Written in a comfortable, conversational style, it grabs the reader’s attention immediately, sparking their curiosity and keeping them engaged throughout each chapter while they seek and find answers to questions posed at the beginning of each section. A true joy to read. I recommend it highly for both traditional and flipped classrooms.”


─ Peggy Cotter, PhD, Professor, Department of Microbiology and Immunology, UNC School of Medicine






List and ASM Member Price: $100

June 2016. 850 pages (EST), full-color illustrations.  Hardcover or eBook.


Questions?  Contact books@asmusa.org










Antibiotics: Challenges, Mechanisms, Opportunities Q&A

Christopher Walsh and Timothy Wencewicz, authors of the new Antibiotics: Challenges, Mechanisms, Opportunities, answer our questions about their new book and the current state of antibiotic development.  


Visit ASMscicence.org to learn more about Antibiotics: Challenges, Mechanisms, Opportunities 


Has the environment surrounding antibiotic research changed from 2003 to the 2016 time frame and publication of Antibiotics: Challenges, Mechanisms, Opportunities?

The past decade has seen a substantially broader appreciation by nonscientists, including government agencies, public media, of the threat posed by multidrug resistant bacterial pathogens, whether Neisseria gonnorheae, fluoroquinolone resistant Pseudomonas aeruginosa, carbapenem resistant enterobacteriacae, and multidrug resistant Acinetobacter baumanii. Over the interevening 13 years much has been learned from bacterial genomics, from the prospects of combination therapy, and from the examination of underutilized targets that suggest there are new opportunities for new molecules. Third, Merck and Roche, to name two pharmaceutical companies, seem to have re-entered the antibiotic research and development arena in a significant way, emphasizing the unmet medical needs.


What inspired you to work on the new book Antibiotics: Challenges, Mechanisms, Opportunities?

Opportunity to collaborate with Tim Wencewicz as a continuation of five years of discussion on the future of antibiotics, and  as a result of the course he has taught  at Wash U on antibiotics. We have a belief that in addition to all the stewardship  improvements for prescribing antibiotics appropriately there is a continuing and pressing need for finding new antibiotics from the two main historical sources: antibiotic molecules from Nature and antibiotics from synthetic chemical frameworks. This  is the chemocentric hypothesis at the heart of the new book and it does not exist in any other publication. We think it will offer a broad readership insights and encouragement to pursue the next generation of antibiotics from a contemporary knowledge base about the two major discovery axes: when, where and why microbes make antibiotics and how 50 years of medicinal chemistry practice  (1960-2010) has enabled us to keep pace (barely) with new waves of bacterial pathogens.


What do you think is the biggest obstacle to future antibiotic development?

In addition to finding new molecular scaffolds, from Nature or from synthetic chemical library collections, it is likely those will often only be starting points  for medicinal chemistry optimization of various desired therapeutic properties. Thus one needs a confluence of microbiology and medicinal chemistry. The historically “unculturable” dark matter of the microbiome may offer promise of new molecular frameworks. Two of the challenges facing researchers and practioners in the antibiotic arena will be development of broad spectrum vs narrow spectrum antibiotics and the real time assays for pathogen identification, and the shift to more combination therapy to parallel the strategies used in antiviral and anticancer therapeutic regimens.


Where is the most potential for future antibiotic development?

A  particularly pressing set of problems is to find new generations of antibiotics that are active against multidrug resistant Gram-negative bacterial pathogens, whether colistin-resistant acinetobacters, fluoroquinolone resistant pseudomonads, and carbapenem resistant enterobacteriacae. Two underdeveloped targets in those pathogens are (1) the cell-wall  transglycosylases that build the glycan chains of the peptidoglycan layer and (2)  the assembly of the lipid A core of the lipolysaccharide component of the outer leaflet of the outer membrane.


What is one thing you would like the general public to know about where antibiotic research is heading?

We are at a point where the antibiotic cupboard is approaching empty in terms of being able to treat life-threatening bacterial infections successfully in each patient.  There is now widespread acknowledgement of how important antibiotics remain to the health of communities, large and small. It is encouraging that academic research teams, philanthropic organizations and NGOs, biotechnology startup companies, and even some of the large Pharma companies that had exited the therapeutic arena a decade or more ago, have come back to the problems. Application of smart screens, new methods for culturing the previously “unculturable” microbiome, discovery of synergistic antibiotic combinations, and detailed investigation of under-examined bacterial enzyme classes , such those that cleave ATP  and GTP to power bacterial machinery, offer promise of next generation antibiotic scaffolds.


Why did you choose to publish your book with ASM Press?

The American Society of Microbiology is the Learned Society committed to all aspect of microbial life, including bacteria in their many manifestations. They were the obvious choice as publisher back in 2003 and remain even more so today as they not only provide a forum for scientific knowledge and advances around antibiotics and their bacterial targets but are also active catalysts in the strategic, policy and stewardship discussions and debates that are central to an integrated antibiotic strategy going forward. 

Purchase These New 2015 ASM Press Titles!

This page presents recently published ASM Press titles.  To view the full descriptions, table of contents, or to purchase these titles please follow the links below.  

To view our full list of hundreds of publications, please visit ASMscience.org




Zoonoses: Infectious Diseases Transmissible between Animals and Humans, Fourth Edition

Authors: Rolf Bauerfeind, Justus Liebig, Alexander von Graevenitz, Peter Kimmig, Hans Gerd Schiefer, Tino Schwarz, Werner Slenczka, Horst Zahner

A valuable clinician’s and laboratorian’s reference that covers zoonotic pathogens as agents of emergence and reemergence of zoonotic diseases, opportunistic zoonotic infections, risks of iatrogenic transmission and xenotransplantation, imported zoonotic infections, food-borne zoonoses, and transmissible spongiform encephalopathies

Paperback or eBook. 2015. 532 pages. Full-color illustrations, Index. 

ASM Member Price: $80
List Price: $100


 9781555817459 Microbial Biofilms, Second Edition

Editors: Mahmoud Ghannoum, Matthew Parsek, Marvin Whiteley, Pranab K. Mukherjee

Microbial Biofilms  takes the reader on an exciting, extensive review of bacterial and fungal biofilms, ranging from basic molecular interactions to innovative therapies, with particular emphasis on the division of labor in biofilms, new approaches to combat the threat of microbial biofilms, and how biofilms evade the host defense.  It is a useful reference for researchers and clinicians.

Paperback or eBook.  2015. 440 pages, full-color illustrations, index.

ASM Member Price: $128
List Price: $160 



Metabolism and Bacterial Pathogenesis

Editors: Tyrrell Conway, Paul S. Cohen

Metabolism and Bacterial Pathogenesis compiles the current thinking of researchers breaking new ground in understanding how bacterial metabolism is foundational to pathogenesis.  Beginning with overviews of bacterial metabolism and pathogenesis, the book presents expert perspectives on a wide range of diseases and bacteria that serve as model systems for both in vitro and in vivo investigations. Metabolism and Bacterial Pathogenesis will be a valuable resource for biomedical professionals and medical microbiology researchers, especially those in fields related to the microbiome.

Hardcover or eBook. 380 pages, full-color illustrations, index.

ASM Member Price: $128
List Price: $160 


 9781555819200 Mobile DNA III

Editors: Nancy L. Craig, Michael Chandler, Martin Gellert, Alan M. Lambowitz, Phoebe A. Rice, Suzanne B. Sandmeyer

This new edition of the bestselling series on movable genetic elements highlights the many exciting advances in the field over the last decade, including conservative site-specific recombination, programmed rearrangements, DNA-only transposons, and LTR, and non-LTR retrotransposons.

Hardcover or eBook. 1,350 pages, full-color illustrations, index.

ASM Member Price: $128
List Price: $160 


9781555818975 Plasmids: Biology and Impact in Biotechnology and Discovery

Editors: Marcelo E. Tolmasky, Juan C. Alonso

An excellent textbook for upper-level undergraduate and graduate courses in the biosciences that features a series of expertly written chapters describing the latest advances in the basic knowledge of plasmid biology, the specialized functions plasmids confer to the host cell, and the practical utilization of plasmids for discovery, medicine, and agriculture

Hardcover or eBook. 718 pages, full-color illustrations, index.

ASM Member Price: $120
List Price: $150 


 9781555817350 Antibodies for Infectious Diseases

Editors: James E. Crowe, Diana Boraschi, Rino Rappuoli

Provides a broad survey across important aspects for understanding mechanisms of immunity to infectious disease, including general features of antibodies and approaches to antibody discovery, individual chapters highlighting antibodies against particular pathogens, and state-of-the-art technical advances and expression systems

Hardcover or eBook. 457 pages, full-color illustrations, index.

ASM Member Price: $120
List Price: $150 


9781555818784 Enterohemorrhagic Escherichia coli and Other Shiga Toxin- Producing E. coli

Editors: Vanessa Sperandio, Carolyn J. Hovde

Useful as a textbook for advanced courses in microbiology, food safety, infectious disease, or microbial pathogenesis, the text presents the most current, relevant research overview from a multidisciplinary, international group of expert authors concerned with tracking, deciphering, intervening, and understanding the diseases caused by EHEC and STEC.

Hardcover or eBook.  2015. 550 pages, full-color illustrations, Index.

ASM Member Price: $120
List Price: $150 


MCM11e covers stacked Manual of Clinical Microbiology, 11th Edition

Editors: James H. Jorgensen, Michael A. Pfaller, Karen C. Carroll, Guido Funke, Marie Louise Landry, Sandra S. Richter, David W. Warnock

Revised by a collaborative, international, interdisciplinary team of editors and authors, this edition includes the latest applications of genomics and proteomics and is filled with current findings regarding infectious agents, leading-edge diagnostic methods, laboratory practices, and safety guidelines. This seminal reference of microbiology continues to set the standard for state-of-the-science laboratory practice as the most authoritative reference in the field of microbiology.

Two-Volume Hardcover Set or eBook.  2015. 2,900 pages, full-color illustrations, index.

ASM Member Price - Print: $239 / Bundle: (Print & eBook) $360
List Price - Print: $299 / Bundle: (Print & eBook) $450


bothcovers2 Principles of Virology, 4th Edition

Authors: Jane Flint, Vincent R. Racaniello, Glenn F. Rall, Anna Marie Skalka

Principles of Virology is the leading virology textbook because it does more than collect and present facts about individual viruses. Instead, it facilitates an understanding of basic virology by examining the shared processes and capabilities of viruses. This fully updated edition of the leading virology textbook represents the rapidly changing field of virology.

Paperback or eBook. 2015. Both volumes include full-color illustrations, glossary, index. 

Volume I: Molecular Biology (574 pages)
Volume II: Pathogenesis and Control (437 pages)
List and ASM Member Price: $100

Bundle: Volumes I and II
List and ASM Member Price: $180