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Monday, 23 April 2018 19:16

Do the Bugs in your Gut Cause Parkinson’s Disease? A Discussion with Sarkis Mazmanian

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Sarkis Mazmanian

Sarkis Mazmanian is a professor at California Institute of Technology who studies how the gut microbiome influences the development and function of the nervous system, the “Gut-Brain Axis”. Dr. Mazmanian has discovered that the microbiome influences the development of Parkinson’s Disease (PD), a neurodegenerative disease caused by the loss of dopamine-producing cells in the brain that affects motor function.

Dr. Mazmanian talks about the evidence that the gut microbiome influences PD, implications of this research for the diagnosis and treatment of PD, the involvement of the microbiome in other neurological conditions, and people freezing away their poop for fecal transplants.

The MicroCase for listeners to solve is about Mortimer Dinglehopper, a retired oil tycoon who becomes dangerously ill after his ritual nighttime dessert.


  • Karl Klose, Ph.D. (UTSA)
  • Sarkis Mazmanian, Ph.D. (California Institute of Technology)
  • Janakiram Seshu, Ph.D. (UTSA) Carlos Paladini, Ph.D. (UTSA)
  • Carlos Paladini, Ph.D. (UTSA)

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Last modified on Monday, 23 April 2018 19:27
Karl Klose

Karl Klose, Ph.D. is a Professor of Microbiology at the University of Texas San Antonio, the Director of the South Texas Center for Emerging Infectious Diseases (STCEID), and host of microTalk. He oversees the research on infectious diseases that is carried out in his laboratory by undergraduate, Masters’, and Ph.D. students, as well as research staff. He also teaches microbiology to undergraduate and graduate students.

Karl is enthusiastic about enlightening people to the fascinating world of microbes.  He has given two TED talks on antibiotic resistance. He has been a visiting professor in Kolkata India and Valparaiso Chile.  He has spent the past two years visiting ASM branch meetings through the Distinguished Lecturer program.  You can find Karl on Twitter and you can find STCEID on TwitterFacebook, and Instagram.